Sodium chenodeoxycholate
Suppliers
Names
[ CAS No. ]:
2646-38-0
[ Name ]:
Sodium chenodeoxycholate
[Synonym ]:
sodium sat of chenodeoxycholic acid
Chenodeoxycholate sodium salt
Chenodeoxycholic acid sodium
Chenodeoxycholic acid sodium salt
UNII:6V4571KSKE
sodium chenodexoycholate
5β-Cholanic acid-3α,7α-diol
sodium chenodeoxycholate
sodiumchenodesoxycholate
3α,7α-Dihydroxy-5β-cholanic acid
Chenodeoxycholic acid sodium salt,Chenodesoxycholic acid
ChenodiolChenodesoxycholic acid
chenodesoxycholate de sodium
Sodium (3α,5β,7α)-3,7-dihydroxycholan-24-oate
cenodeoxycholate
Cholan-24-oic acid, 3,7-dihydroxy-, sodium salt, (3α,5β,7α)- (1:1)
Chemical & Physical Properties
[ Boiling Point ]:
547.1ºC at 760mmHg
[ Melting Point ]:
298 °C(dec.)
[ Molecular Formula ]:
C24H39NaO4
[ Molecular Weight ]:
414.55
[ Flash Point ]:
298.8ºC
[ Exact Mass ]:
414.274597
[ PSA ]:
80.59000
[ LogP ]:
3.14320
[ Vapour Pressure ]:
2.98E-14mmHg at 25°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- FZ2231000
- CHEMICAL NAME :
- 5-beta-Cholan-24-oic acid, 3-alpha,7-alpha-dihydroxy-, monosodium salt
- CAS REGISTRY NUMBER :
- 2646-38-0
- LAST UPDATED :
- 198508
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C24-H39-O4.Na
- MOLECULAR WEIGHT :
- 414.62
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 11,2499,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1450 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from small intestine Skin and Appendages - hair
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 11,2499,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 114 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 11,2499,1977
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H312-H332-H351
[ Precautionary Statements ]:
P280-P281
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
20/21/22-40
[ Safety Phrases ]:
S22;S36
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
FZ2231000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Infect. Immun. 82(9) , 3531-41, (2014)
Gastroesophageal reflux (GER) frequently occurs in patients with respiratory disease and is particularly prevalent in patients with cystic fibrosis. GER is a condition in which the duodenogastric cont...
Gastroenterology 139 , 1549, (2010)
Sodium chenodeoxycholate (CDC) accelerates colonic transit in health. Our aim was to examine pharmacodynamics (colonic transit, bowel function) and pharmacogenetics of CDC in constipation-predominant ...
Nutr. Cancer 16 , (1991)
Two bile salts, sodium chenodeoxycholate and sodium deoxycholate, induced a DNA repair response in the bacterium Escherichia coli. Similarly, a bile acid and a bile salt, chenodeoxycholic acid and sod...