4,4′-Thiodiphenol

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Names

[ Name ]:
4,4′-Thiodiphenol

[Synonym ]:
Bis(4-hydroxyphenyl) sulfide
Thiobisphenol
4,4'-Thiobisphenol
MFCD00002349
Phenol, 4,4'-thiobis-
4-(4-hydroxyphenyl)sulfanylphenol
4-hydroxyphenyl sulphide
p,p'-Dihydroxydiphenyl sulfide
4,4′-Thiodiphenol
4,4'-thiodiphenol
4,4'-Thiobis-phenol
4,4'-dihydroxyldiphenyl sulfide
4,4'-Sulfanediyldiphenol
4,4'-Dihydroxydiphenyl sulfide
4,4-Thiodiphenol
EINECS 220-197-9
Phenol,4,4'-thiobis
4,4'-Dihydroxy diphenyl sulfide

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
452.7±30.0 °C at 760 mmHg

[ Melting Point ]:
154-156 °C(lit.)

[ Molecular Formula ]:
C₁₂H₁₀O₂S

[ Molecular Weight ]:
218.272

[ Flash Point ]:
219.7±23.3 °C

[ Exact Mass ]:
218.040146

[ PSA ]:
65.76000

[ LogP ]:
3.34

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.717

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SN0800000

CHEMICAL NAME :: Phenol, 4,4'-thiodi-

CAS REGISTRY NUMBER :: 2664-63-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C12-H10-O2-S

MOLECULAR WEIGHT :: 218.28

WISWESSER LINE NOTATION :: QR DSR DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: A408,1971

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: A408,1971 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3362 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: A408,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 13,154,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >10250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: A408,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 3 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0044 No. of Facilities: 69 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 1146 (estimated)

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S27-S36/37/39-S45

[ RIDADR ]:
UN 3261 8/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
SN0800000

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
29309070

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Phenol,4,4'-sulfinylbis-
Phenol
4-Bromophenol
4,4'-Thiodianiline
4-Iodophenol
4-HYDROXYBENZENEDIAZONIUM
4-Chlorophenol
Sulfonium, tris(4-hydroxyphenyl)-, chloride
Water

DownStream

1-nitro-3-[4-[4-(3-nitrophenoxy)phenyl]sulfanylphenoxy]benzene
Bis(4-methoxyphenyl) sulfide
Temephos
4-Mercaptophenol
Bis-(4-cyanatophenyl)-sulfide
4,4'-Sulfonyldiphenol
Phenol,4,4'-sulfinylbis-
Oxirane,2,2'-[thiobis(4,1-phenyleneoxymethylene)]bis-
acetic acid,4-(4-hydroxyphenyl)sulfanylphenol
2-[4-[4-(1-carboxyheptoxy)phenyl]sulfanylphenoxy]octanoic acid

Customs

[ HS Code ]: 29309070

Articles

Screening of bisphenol A, triclosan and paraben analogues as modulators of the glucocorticoid and androgen receptor activities.

Toxicol. In Vitro 29(1) , 8-15, (2014)

A homeostasis of the glucocorticoid and androgen endocrine system is essential to human health. Their disturbance can lead to various diseases, for example cardiovascular, inflammatory and autoimmune ...

[Materials for the establishment of maximum allowable concentrations of bis (4-oxyphenyl) sulfide in the working zone air].

Gig. Tr. Prof. Zabol. (1) , 31-2, (1991)

4,4′-DIAMIDINO-1,3-DIPHENOXYPROPANE DIHYDROCHLORIDE
4,4′-bis(N-carbazolyl)biphenyl
[4,4′-bichroman]-2,2′-dione
4,4′-methylenedianiline
4,4′-Diamino-2,2′-stilbenedisulfonic acid
4,4′-ddt 13c12
7-Methoxy-3-({1-[3-(propan-2-yl)-1,2,4-thiadiazol-5-yl]piperidin-4-yl}methyl)-3,4-dihydroquinazolin-4-one
3-{[1-(6-Ethyl-5-fluoropyrimidin-4-yl)piperidin-4-yl]methyl}-7-methoxy-3,4-dihydroquinazolin-4-one
4-Chloro-2-[4-(cyclopropanesulfonyl)-1,4-diazepan-1-yl]-1,3-benzothiazole
4-(3,5-dimethyl-1H-pyrazol-1-yl)-2-methyl-6-[4-(1-phenylethyl)piperazin-1-yl]pyrimidine
2-[4-(Cyclopropanesulfonyl)-1,4-diazepan-1-yl]-4,5-dimethyl-1,3-benzothiazole
2-[4-(Cyclopropanesulfonyl)-1,4-diazepan-1-yl]-4,6-dimethyl-1,3-benzothiazole
6-Bromo-2-[4-(cyclopropanesulfonyl)piperazin-1-yl]quinazoline
6-Bromo-4-[4-(cyclopropanesulfonyl)piperazin-1-yl]quinazoline
7-Methoxy-3-({1-[2-(trifluoromethyl)pyridin-4-yl]piperidin-4-yl}methyl)-3,4-dihydroquinazolin-4-one
7-Methoxy-3-({1-[3-(methoxymethyl)-1,2,4-thiadiazol-5-yl]piperidin-4-yl}methyl)-3,4-dihydroquinazolin-4-one

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