Triforine

Suppliers

Names

[ Name ]:
Triforine

[Synonym ]:
Saprol
N,N'-(1,4-piperazinediyl bis (2,2,2-trichloro) ethylidene) bis formamide
Triforin
CW 524
N,N’-[1,4-piperazinediylbis(2,2,2-trichloroethylidene)]bis[formamide]
CELA 50
N,N'-[1,4-Piperazinediylbis(2,2,2-trichloro-1,1-ethanediyl)]diformamide
Caswell No. 890AA
Triforine
EINECS 247-872-0
1,4-bis-(2,2,2-trichloro-1-formamidoethyl)-piperazine
N,N'-[Piperazine-1,4-diylbis(2,2,2-trichloroethane-1,1-diyl)]diformamide
N-[2,2,2-trichloro-1-[4-(2,2,2-trichloro-1-formamidoethyl)piperazin-1-yl]ethyl]formamide
Formamide, N,N'-[1,4-piperazinediylbis(2,2,2-trichloroethylidene)]bis-
N,N’-{piperazine-1,4-diylbis[(trichloromethyl)methylene]}diformamide
MFCD00055521
N,N'-[Piperazin-1,4-diylbis(2,2,2-trichlorethan-1,1-diyl)]diformamid
N,N'-(2,2,2,2',2',2'-hexachloro-1,1'-piperazine-1,4-diyl-diethyl)-bis-formamide
Biformylchlorazin
Funginex
N,N’-[piperazine-1,4-diylbis(2,2,2-trichloroethane-1,1-diyl)]diformamide

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
561.5±50.0 °C at 760 mmHg

[ Melting Point ]:
155ºC (decomposes)

[ Molecular Formula ]:
C₁₀H₁₄Cl₆N₄O₂

[ Molecular Weight ]:
434.96

[ Flash Point ]:
293.4±30.1 °C

[ Exact Mass ]:
431.924805

[ PSA ]:
64.68000

[ LogP ]:
4.61

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.571

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TK9200000

CHEMICAL NAME :: Piperazine, 1,4-bis(1-formamido-2,2,2-trichloroethyl)-

CAS REGISTRY NUMBER :: 26644-46-2

BEILSTEIN REFERENCE NO. :: 0626358

LAST UPDATED :: 199612

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C10-H14-Cl6-N4-O2

MOLECULAR WEIGHT :: 434.98

WISWESSER LINE NOTATION :: T6N DNTJ AYMVHXGGG DYMVHXGGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 180 uL/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Taste) - change in function

REFERENCE :: AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 4,554,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year: 4,81,1976/1977

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4500 mg/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,853,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,853,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A413,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,853,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A413,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A413,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,853,1991 *** REVIEWS *** TOXICOLOGY REVIEW 27ZTAP "Clinical Toxicology of Commercial Products--Acute Poisoning," 3rd ed., Gleason, M.N., et al., eds., Baltimore, Williams and Wilkins, 1969 Volume(issue)/page/year: 3,126,1969 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2601 No. of Facilities: 31 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 644 (estimated) No. of Female Employees: 123 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H332

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
52/53-20

[ Safety Phrases ]:
61

[ RIDADR ]:
UN3077 (solid); UN3082 (liquid)

[ RTECS ]:
TK9200000

[ HS Code ]:
2933599019

Customs

[ HS Code ]: 2933599019

[ Summary ]:
2933599019 n,n'-(piperazine-1,4-diylbis(2,2,2-trichloroethane-1,1-diyl))diformamide。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

Articles

A new 2D-TLC bioautography method for the discovery of novel antifungal agents To control plant pathogens.

J. Nat. Prod. 63(8) , 1050-4, (2000)

A new bioassay has been developed combining the simplicity of direct bioautography with the improved chromatographic resolution of 2D-TLC. Mixtures of structurally diverse antifungal agents were teste...

[Determination of triforin in water and soil by a thin-layer chromatographic method].

Gig. Sanit. (1) , 46-7, (1981)

Ultrastructure of gastric epithelium after exposure to mild environmental agents (sodium nitrate, saprol).

J. Environ. Pathol. Toxicol. Oncol. 10(6) , 297-300, (1990)

Environmental chemical agents usually affect the human organism in combination rather than alone. The objective of this study was to determine the effect on the gastric mucosa of the herbicide Saprol ...