5H-[1,3]Dioxolo[4,5-f]indole

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Names

[ CAS No. ]:
267-48-1

[ Name ]:
5H-[1,3]Dioxolo[4,5-f]indole

[Synonym ]:
5H-[1,3]Dioxolo[4,5-f]indole
5,6-methylenedioxy-1H-indole
MFCD00046910
5,6-Methylenedioxyindole
EINECS 205-976-3
5H-1,3-Dioxolo[4,5-f]indole
5H-1,3-Dioxolo(4,5-f)indole
5H-1,5-f]indole

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
334.7±11.0 °C at 760 mmHg

[ Molecular Formula ]:
C9H7NO2

[ Molecular Weight ]:
161.157

[ Flash Point ]:
122.5±9.5 °C

[ Exact Mass ]:
161.047684

[ PSA ]:
34.25000

[ LogP ]:
2.00

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.721

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JI4650000
CHEMICAL NAME :
5H-1,3-Dioxolo(4,5-f)indole
CAS REGISTRY NUMBER :
267-48-1
BEILSTEIN REFERENCE NO. :
0132678
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C9-H7-N-O2
MOLECULAR WEIGHT :
161.17
WISWESSER LINE NOTATION :
T C565 DO FO LM EHJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01508

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
20/21/22

[ Safety Phrases ]:
36

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-nitro-6-(2-nitroethenyl)-1,3-benzodioxole
  • trans-β-dimethylamino- 4,5-methylenedioxy-2-nitrostyrene
  • 2-(6-bromo-benzo[1,3]dioxol-5-yl)-ethylamine
  • 5-nitro-6-prop-2-enyl-1,3-benzodioxole
  • Methylenedioxyphenethylamine
  • 1,3-Benzodioxole-5-carboxaldehyde,6-nitro-
  • 6-prop-2-enyl-1,3-benzodioxol-5-amine

DownStream

  • 7-piperidin-4-yl-5H-[1,3]dioxolo[4,5-f]indole
  • 7-(2-pyrrolidin-1-ylethyl)-5H-[1,3]dioxolo[4,5-f]indole
  • 1-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-2-morpholin-4-ylethane-1,2-dione
  • 7-[2-[4-(4-fluorophenyl)piperazin-1-yl]ethyl]-5H-[1,3]dioxolo[4,5-f]indole
  • 1-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-2-(4-phenylpiperazin-1-yl)ethane-1,2-dione
  • 1-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-2-piperidin-1-ylethane-1,2-dione
  • 7-(2-morpholin-4-ylethyl)-5H-[1,3]dioxolo[4,5-f]indole
  • 7-(2-piperidin-1-ylethyl)-5H-[1,3]dioxolo[4,5-f]indole
  • (5E)-1-phenyl-5-[(1-phenylpyrrol-2-yl)methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
  • 1-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)-2-pyrrolidin-1-ylethane-1,2-dione

Related Compounds

  • 2H,5H-[1,3]dioxolo[4,5-f]indole
  • 6-methyl-5H-[1,3]dioxolo[4,5-f]indole
  • 6-phenyl-5H-[1,3]dioxolo[4,5-f]indole
  • 5H-[1,3]Dioxolo[4,5-f]indole-6,7-dione
  • 6,7-dihydro-5H-[1,3]dioxolo[4,5-f]indole
  • 5-tert-pentyl-5H-[1,3]dioxolo[4,5-f]indole
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
  • N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine