LOFEPRAMINE HYDROCHLORIDE

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Names

[ Name ]:
LOFEPRAMINE HYDROCHLORIDE

[Synonym ]:
N-(4-Chlorobenzoylmethyl)-3-(10,11-dihydro-5h-dibenz[b,f]azepin-5-yl)-n-methylpropylamine hydrochloride
1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone,hydrochloride
Lofepramine hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
575ºC at 760 mmHg

[ Molecular Formula ]:
C₂₆H₂₈Cl₂N₂O

[ Molecular Weight ]:
455.42

[ Flash Point ]:
301.6ºC

[ Exact Mass ]:
454.15800

[ PSA ]:
23.55000

[ LogP ]:
6.64850

[ Vapour Pressure ]:
3.17E-13mmHg at 25°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM6485000

CHEMICAL NAME :: Acetophenone, 4'-chloro-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5 -yl)propyl)methylamin o)-, hydrochloride

CAS REGISTRY NUMBER :: 26786-32-3

LAST UPDATED :: 199707

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C26-H27-Cl-N2-O.Cl-H

MOLECULAR WEIGHT :: 455.46

WISWESSER LINE NOTATION :: T676 BN IH JHJ B3N1&1VR DG &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 920 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2800 mg/kg/4W-I

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18200 mg/kg/26W-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - changes in potassium

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 180 mg/kg

SEX/DURATION :: female 17-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 630 mg/kg

SEX/DURATION :: female 14 day(s) pre-mating female 1-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 150 mg/kg

SEX/DURATION :: female 9-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1200 mg/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 100 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,155,1993

Related Compounds

Tyrocidine, hydrochloride
Triprolidine hydrochloride
Minoxidil hydrochloride
Elacridar hydrochloride
dodecylamine hydrochloride
Azetidine, hydrochloride, homopolymer (9CI)
(1S,3aR,3bR,5S,5aR,7S,9aR,9bR,11R,11aR)a1a[(2S)a 2,6adimethoxya6amethylheptana2ayl]a3a,3b,6,6,9aa pentamethylahexadecahydroa1Ha cyclopenta[a]phenanthrenea5,7,11atriol
(3beta,6alpha,12beta,20R)-20,24-Epoxydammarane-3,6,12,25-tetrol
(1S,3aR,3bR,5aR,7S,9aR,9bR,11R,11aR)a7a(acetyloxy)a1a [(2S)a2,6adihydroxya6amethylheptana2ayl]a 3a,3b,6,6,9aapentamethylahexadecahydroa1Ha cyclopenta[a]phenanthrena11ayl acetat
Phosphorothioic acid O-[2-Chloro-1-(1-methylethyl)-1H-imidazol-4-yl] O,O-diethyl ester
2,2-Difluoro-1-(2-methyl-1,3-thiazol-5-yl)ethan-1-amine
(1R,3aR,3bS,9bR,11aR)-1-Hydroxy-11a-methyl-1,2,3,3a,3b,4,5,6,8,9,9b,10,11,11a-tetradecahydro-7H-cyclopenta[a]phenanthren-7-one
2-Chloro-6-[(4,6-dimethoxy-2-pyrimidinyl)thio]benzoic acid octyl ester
2-Amino-N-[3-cyano-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazol-5-yl]acetamide
2-(4-Chloro-2-fluoro-5-hydroxyphenyl)-1H-isoindole-1,3(2H)-dione
2,6-Dibromo-4-cyanophenyl pentanoate

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