Harringtonine

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Names

[ CAS No. ]:
26833-85-2

[ Name ]:
Harringtonine

[Synonym ]:
harringtonine
O-[(2R)-2,5-Dihydroxy-2-(2-methoxy-2-oxoethyl)-5-methylhexanoyl]cephalotaxine
Cephalotaxine, O-[(2R)-2,5-dihydroxy-2-(2-methoxy-2-oxoethyl)-5-methyl-1-oxohexyl]-
Harringtonine (8CI)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
679.4±55.0 °C at 760 mmHg

[ Melting Point ]:
73-75ºC

[ Molecular Formula ]:
C28H37NO9

[ Molecular Weight ]:
531.595

[ Flash Point ]:
364.7±31.5 °C

[ Exact Mass ]:
531.246826

[ PSA ]:
123.99000

[ LogP ]:
2.58

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.610

[ Storage condition ]:
-20℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FK0250000
CHEMICAL NAME :
Cephalotaxine, 4-methyl-, 2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate (ester), (3(R))-
CAS REGISTRY NUMBER :
26833-85-2
LAST UPDATED :
199703
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C28-H37-N-O9
MOLECULAR WEIGHT :
531.66
WISWESSER LINE NOTATION :
T5 H5 F675 1A T AX IO KO QN BU JHT&&TTJ CO1 DOVXQ1VQ2XQ1&1 T1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4170 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
4200 ug/kg/5D-I
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP Blood - leukopenia Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5200 ug/kg/5D-I
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP Blood - leukopenia Related to Chronic Data - death
TYPE OF TEST :
Micronucleus test

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
200 ug/L
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 7,173,1986

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
UN 1544

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Precursor & DownStream

Precursor

  • 4-benzyloxy-7,7-dimethyl-2-oxo-oxepane-4-carbonyl chloride
  • (Ξ)-4-benzyloxy-7,7-dimethyl-2-oxo-oxepane-4-carboxylic acid (3aR)-2-methoxy-(3arC4,14bc)-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[b][1,3]dioxolo[4',5':4,5]benzo[1,2-d]pyrrolo[1,2-a]azepin-1t-yl ester
  • Cephalotaxine

DownStream


Related Compounds

  • harringtonine
  • harringtonine
  • Isoharringtonine
  • 2'R-HARRINGTONINE
  • 2-(4-Bromotriazol-1-yl)ethanamine;hydrochloride
  • (1-(Cyclopropylsulfonyl)cyclopropyl)methanol
  • {2,2-Difluorobicyclo[3.1.0]hexan-6-yl}methanamine
  • (1-((3,3-Difluoroazetidin-1-yl)sulfonyl)cyclopropyl)methanol
  • Benzyl 2-cyclopropylsulfonylacetate
  • benzyl 2-chloro-5H,6H,7H-pyrrolo[3,4-b]pyridine-6-carboxylate
  • tert-Butyl 6-bromo-3-(methylcarbamoyl)-1H-indazole-1-carboxylate
  • 8-Chloro-2-(4-hydroxyphenyl)-4-oxo-4H-chromene-7-carbonitrile
  • 8-Chloro-2-(4-(2-hydroxyethoxy)phenyl)-4H-chromen-4-one
  • Methyl 3-(2-hydroxyethoxy)cyclopentane-1-carboxylate
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