Cephalotaxine,3-[4-methyl (2R,3S)-2,3-dihydroxy-2-(3-methylbutyl)butanedioate]

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Names

[ CAS No. ]:
26833-86-3

[ Name ]:
Cephalotaxine,3-[4-methyl (2R,3S)-2,3-dihydroxy-2-(3-methylbutyl)butanedioate]

[Synonym ]:
iso-harringtonine

Chemical & Physical Properties

[ Density]:
1.35g/cm3

[ Boiling Point ]:
632.5ºC at 760mmHg

[ Melting Point ]:
70.75°C

[ Molecular Formula ]:
C28H37NO9

[ Molecular Weight ]:
531.59500

[ Exact Mass ]:
531.24700

[ PSA ]:
123.99000

[ LogP ]:
1.98440

[ Vapour Pressure ]:
7.21E-17mmHg at 25°C

[ Index of Refraction ]:
1.607

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NR2935500
CHEMICAL NAME :
Isoharringtonine
CAS REGISTRY NUMBER :
26833-86-3
LAST UPDATED :
198909
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C28-H37-N-O9

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
27950 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
14600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
26110 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
13200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988

Related Compounds

  • (6-Chloro-3-pyridazinyl)(3,4-dihydro-2(1H)-isoquinolinyl)methanone
  • 3-Bromo-2-([1-(chloromethyl)cyclopropyl]methyl)thiophene
  • 3-[(6-Ethoxy-2-pyridinyl)oxy]benzenamine
  • 2-(4-(Aminomethyl)phenyl)-N-(2-fluorophenyl)acetamide
  • 1-(2-p-Fluorophenylethyl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline
  • 1-(6-Ethoxypyridin-2-yl)piperidin-4-amine
  • (3S)-5-Methyl-3-{[(pyrrolidin-3-yl)formamido]methyl}hexanoic acid
  • (Phenyl)-[2-(4-methylphenyl)-1-(piperidin-1-yl)ethyl]-ketone
  • Propyl 3-(aminomethyl)-5-methylhexanoate
  • Propyl (S)-3-(aminomethyl)-5-methylhexanoate
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