Cephalotaxine,3-[4-methyl (2R,3S)-2,3-dihydroxy-2-(3-methylbutyl)butanedioate]

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Names

[ CAS No. ]:
26833-86-3

[ Name ]:
Cephalotaxine,3-[4-methyl (2R,3S)-2,3-dihydroxy-2-(3-methylbutyl)butanedioate]

[Synonym ]:
iso-harringtonine

Chemical & Physical Properties

[ Density]:
1.35g/cm3

[ Boiling Point ]:
632.5ºC at 760mmHg

[ Melting Point ]:
70.75°C

[ Molecular Formula ]:
C28H37NO9

[ Molecular Weight ]:
531.59500

[ Exact Mass ]:
531.24700

[ PSA ]:
123.99000

[ LogP ]:
1.98440

[ Vapour Pressure ]:
7.21E-17mmHg at 25°C

[ Index of Refraction ]:
1.607

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NR2935500
CHEMICAL NAME :
Isoharringtonine
CAS REGISTRY NUMBER :
26833-86-3
LAST UPDATED :
198909
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C28-H37-N-O9

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
27950 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
14600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
26110 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
13200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988

Related Compounds

  • 3-[(4-amino-5-methyl-1H-pyrazol-1-yl)methyl]-1-methylpyrrolidin-2-one
  • 2-(4-amino-5-methyl-1H-pyrazol-1-yl)-4-methylpentanoic acid
  • 3-[(3-amino-5-bromo-1H-1,2,4-triazol-1-yl)methyl]-3-methylpyrrolidin-2-one
  • 1-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]-1H-pyrazol-3-amine
  • 5-methyl-1-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]-1H-pyrazol-3-amine
  • 4-bromo-1-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]-1H-pyrazol-3-amine
  • 5-Formyl-3-nitro-1H-pyrrole-2-carboxylic acid
  • 4-bromo-1-(2-ethoxy-2-methylpropyl)-1H-pyrazol-3-amine
  • 3-Amino-1-(2-ethoxy-2-methylpropyl)-1,4-dihydropyridin-4-one
  • 1-[(5-chloropyridin-2-yl)methyl]-3-methyl-1H-pyrazol-4-amine
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