Homoharringtonine
Suppliers
Names
[ CAS No. ]:
26833-87-4
[ Name ]:
Homoharringtonine
[Synonym ]:
Omacetaxine mepesuccinate
MFCD03410264
Homoharringtonine
Cephalotaxine, O-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methyl-1-oxoheptyl]-
Myelostat
O-[(2R)-2,6-Dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine
(-)-homoharringtonine
HOMOHARRINGTONINUM
homoharrigtonine
Synribo
HMoharringtonine
Ceflatonin
Homobarringtonie
HHT
HOMOHARRINGTONIN
CGX 635
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
713.1±60.0 °C at 760 mmHg
[ Melting Point ]:
144-146ºC
[ Molecular Formula ]:
C29H39NO9
[ Molecular Weight ]:
545.621
[ Flash Point ]:
385.1±32.9 °C
[ Exact Mass ]:
545.262512
[ PSA ]:
134.99000
[ LogP ]:
2.70
[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C
[ Index of Refraction ]:
1.605
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
DMSO: soluble20mg/mL, clear
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- FK0260000
- CHEMICAL NAME :
- Cephalotaxine, 4-methyl-, 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester)
- CAS REGISTRY NUMBER :
- 26833-87-4
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C29-H39-N-O9
- MOLECULAR WEIGHT :
- 545.69
- WISWESSER LINE NOTATION :
- T5 H5 F675 1A T AX IO KO QN BU JHT&&TTJ CO1 DOVXQ1VQ3XQ1&1 T1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 7456 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3170 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CMJODS Chinese Medical Journal (Beijing, English Edition). (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1975- Adopted vol. no. 92 in 1979. Volume(issue)/page/year: 92,175,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3948 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988
- TYPE OF TEST :
- LD10 - Lethal Dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 640 ug/kg
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Cardiac - change in rate Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- NCINS* National Cancer Institute Report. (Bethesda, MD 20014) Volume(issue)/page/year: AUG1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1600 ug/kg/5D-I
- TOXIC EFFECTS :
- Cardiac - EKG changes not diagnostic of specified effects Blood - leukopenia Related to Chronic Data - death
- REFERENCE :
- CMJODS Chinese Medical Journal (Beijing, English Edition). (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1975- Adopted vol. no. 92 in 1979. Volume(issue)/page/year: 92,175,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2500 ug/kg/5D-I
- TOXIC EFFECTS :
- Cardiac - EKG changes not diagnostic of specified effects Blood - leukopenia Related to Chronic Data - death
- REFERENCE :
- CMJODS Chinese Medical Journal (Beijing, English Edition). (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1975- Adopted vol. no. 92 in 1979. Volume(issue)/page/year: 92,175,1979
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300
[ Precautionary Statements ]:
P264-P301 + P310
[ Hazard Codes ]:
T+: Very toxic;Xi: Irritant;
[ Risk Phrases ]:
R26/27/28
[ Safety Phrases ]:
36/37/39-45-27-26
[ RIDADR ]:
UN 1544 6
[ WGK Germany ]:
3
[ RTECS ]:
FK0260000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)