N-Octylpyrrolidone
Suppliers
Names
[ CAS No. ]:
2687-94-7
[ Name ]:
N-Octylpyrrolidone
[Synonym ]:
N-Octyl pyrrolidone
caprylyl pyrrolidone
T5NVTJ A8
1-octyl-pyrrolidone
2-Pyrrolidinone, 1-octyl-
1-n-octylazacyclopentan-2-one
1-Octyl-2-pyrrolidinone
N-Octylpyrrolidinone
EINECS 403-700-8
n-octyl-2-pyrrolidone
MFCD00074965
1-Octyl-2-pyrrolidone
N-octyl-2-pyrrolidinone
N-Octylpyrrolidone
N-n-Octylpyrrolidone
1-n-Octyl-2-pyrrolidone
2-Pyrrolidinone,1-octyl
1-Octylpyrrolidin-2-one
N-Octyl-Pyrrolidone
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
303.1±0.0 °C at 760 mmHg
[ Melting Point ]:
−25 °C(lit.)
[ Molecular Formula ]:
C12H23NO
[ Molecular Weight ]:
197.317
[ Flash Point ]:
129.0±9.9 °C
[ Exact Mass ]:
197.177963
[ PSA ]:
20.31000
[ LogP ]:
3.32
[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C
[ Index of Refraction ]:
1.469
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UY5896000
- CHEMICAL NAME :
- 2-Pyrrolidinone, 1-octyl-
- CAS REGISTRY NUMBER :
- 2687-94-7
- BEILSTEIN REFERENCE NO. :
- 1526318
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C12-H23-N-O
- MOLECULAR WEIGHT :
- 197.36
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,475,1988
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,475,1988 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2050 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes Liver - other changes Kidney, Ureter, Bladder - other changes
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,475,1988
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-1290-1125 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8960 mg/kg/28D-I
- TOXIC EFFECTS :
- Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-1290-1125
Safety Information
[ Symbol ]:
GHS05, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H314-H411
[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
C:Corrosive;N:Dangerousfortheenvironment;
[ Risk Phrases ]:
R34;R51/53
[ Safety Phrases ]:
S23-S26-S36/37/39-S45-S1/2
[ RIDADR ]:
UN 3267 8/PG 2
[ WGK Germany ]:
2
[ RTECS ]:
UY5896000
[ Packaging Group ]:
III
[ Hazard Class ]:
8
[ HS Code ]:
2933790090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933790090
[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%
Articles
J. Pharm. Sci. 87(2) , 209-14, (1998)
In a previous study, the enhancing effects of a series of 1-alkyl-2-pyrrolidones (APs; 1-ethyl, 1-butyl, 1-hexyl, and 1-octyl-2-pyrrolidone) on the transport of steroidal permeants across hairless mou...