2-Phenoxyaniline

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Names

[ Name ]:
2-Phenoxyaniline

[Synonym ]:
Benzenamine, 2-phenoxy-
o-Phenoxyaniline
2-Phenoxyaniline
phenoxyaniline
2-phenoxy-phenylamine
Aniline, o-phenoxy-
Aniline,2-phenoxy
MFCD00035765
2-Ade
o-Aminophenyl phenyl ether
2-Phenoxybenzenamine
EINECS 220-254-8
Aniline, 2-phenoxy-
aminophenoxybenzene
Benzenamine,2-phenoxy
2-Aminodiphenyl Ether
2-aminophenyl phenyl ether
2-aminophenylphenyl ether
Nimesulide Impurity 3

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
170 ºC (18 mmHg)

[ Melting Point ]:
46-50 ºC

[ Molecular Formula ]:
C₁₂H₁₁NO

[ Molecular Weight ]:
185.222

[ Flash Point ]:
113 ºC

[ Exact Mass ]:
185.084061

[ PSA ]:
35.25000

[ LogP ]:
2.46

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.619

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BY7940000

CHEMICAL NAME :: Aniline, 2-phenoxy-

CAS REGISTRY NUMBER :: 2688-84-8

BEILSTEIN REFERENCE NO. :: 0777766

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H11-N-O

MOLECULAR WEIGHT :: 185.24

WISWESSER LINE NOTATION :: ZR BOR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 212 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 8,347,1977

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S37/39-S36/37/39

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ RTECS ]:
BY7940000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2922299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-nitrodiphenyl ether
1,4-dichloro-2-(4-nitrophenoxy)benzene
2-Nitrochlorobenzene
Benzoxazole
Iodobenzene
Diphenyl oxide
Phenol
Acetamide, N-(2-chlorophenyl)-2,2,2-trifluoro-
1-Bromo-2-nitrobenzene
POTASSIUMPHENOLATE

DownStream

2-phenoxyphenyl isocyanate
2'-Phenoxymethanesulfonanilide
2-Phenylbenzoxazole
Phenol,2-(2-benzoxazolyl)-
2-Allylphenol
1-(2-BROMO-ETHYL)-3-METHOXY-BENZENE
11-Phenyl-10,11-dihydrodibenzo[b,f][1,4]oxazepine
aminophenol
2-phenoxybenzene-1-sulfonyl chloride
2,2'-Diphenoxy-1,1'-biphenyl

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Synthesis of haptens and protein conjugates for the development of immunoassays for the insect growth regulator fenoxycarb.

J. Agric. Food Chem. 50(1) , 29-40, (2002)

Sensitive and selective enzyme-linked immunosorbent assays (ELISAs) in the immobilized antigen format were developed for fenoxycarb (1), an insect growth regulator (IGR). The parent molecule [ethyl 2-...

Encapsulation of sodium nimesulide and precursors in beta-cyclodextrin.

Org. Biomol. Chem. 1(5) , 873-8, (2003)

Crystalline 1:1 inclusion complexes with beta-cyclodextrin (beta-CD) and the sodium salt of nimesulide (4-nitro-2-phenoxymethanesulfonanilide), and the sodium salt of the derivative 2-phenoxymethanesu...

The first structurally characterised sodium primary amide complex; synthesis and crystal structure of 2-PhOC6H4NHNa· NMe [(CH2) 2NMe2] 2. Cragg-Hine I, et al.

J. Chem. Soc., Dalton Trans. 19 , 2901-2, (1994)