Sphingosine-1-phosphate

Suppliers

Names

[ Name ]:
Sphingosine-1-phosphate

[Synonym ]:
(4E)-2-Amino-3-hydroxy-4-octadecen-1-yldihydrogen-phosphat
(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate D-erythro-Sphingosine 1-phosphate
[(E,2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate
Sphing-4-enine 1-phosphate
4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (4E)-
C18-Sphingosine 1-phosphate
D-erythro-sphingosine-1-phosphate
Sphingosine 1-phosphate
Dihydrogène phosphate de (4E)-2-amino-3-hydroxy-4-octadécèn-1-yle
MFCD00274457
S1P
Sphingosine 1-phosphic acid
(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate,D-erythro-Sphingosine 1-phosphate
D-erythro-Sphingosine 1-phosphate
Somatostatin 1-28
(4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
(4E)-2-Amino-3-hydroxy-4-octadecen-1-yl dihydrogen phosphate

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
548.8±60.0 °C at 760 mmHg

[ Melting Point ]:
190ºC

[ Molecular Formula ]:
C₁₈H₃₈NO₅P

[ Molecular Weight ]:
379.472

[ Flash Point ]:
285.7±32.9 °C

[ Exact Mass ]:
379.248749

[ PSA ]:
122.82000

[ LogP ]:
5.46

[ Vapour Pressure ]:
0.0±3.3 mmHg at 25°C

[ Index of Refraction ]:
1.501

[ Storage condition ]:
−20°C

[ Stability ]:
Moisture, Temperature Sensitive; Hygroscopic

[ Water Solubility ]:
methanol: THF: water (6:3:1): >0.5 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(2S,3R)-2-amino-octadec-4-ene-3-(t-butyl-diphenylsilyloxy)-1-ol-phosphate
(4E,2S,3R)-1,3-Dihydroxy-2-((tert-b
(4S,5R)-4-[[[Bis[1-(2-nitrophenyl)ethoxy]phosphinyl]oxy]Methyl]-2,2-dimethyl-5-(1E)-1-pentadecen-1-yl-3-oxazolidinecarboxylic Acid 1,1-Dimethyleth
(2S,3R,4E)-2-AZIDO-3-(TERT-BUTYLDIMETHYLSILYL)-ERYTHRO-SPHINGOSINE
(2S,3R,4E)-2-amino-3-(tert-butyldimethylsilyloxy)-4-octadecene-1-ol
3-O-(TERT-BUTYLDIMETHYLSILYLOXY)-2-FMOC-ERYTHRO-SPHINGOSINE

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

The novel HDAC inhibitor AR-42-induced anti-colon cancer cell activity is associated with ceramide production.

Biochem. Biophys. Res. Commun. 463 , 545-50, (2015)

In the current study, we investigated the potential activity of AR-42, a novel histone deacetylase (HDAC) inhibitor, against colon cancer cells. Our in vitro results showed that AR-42 induced ceramide...

Higher level of plasma bioactive molecule sphingosine 1-phosphate in women is associated with estrogen.

Biochim. Biophys. Acta 1841(6) , 836-46, (2014)

Both sphingosine 1-phosphate (S1P) and estrogen have been documented to play endothelial protective roles. However, it remains unclear whether estrogen could regulate the anabolism of the bioactive mo...

The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development.

Development 141(23) , 4513-25, (2014)

Low density lipoprotein receptor-related protein 1 (LRP1) is indispensable for embryonic development. Comparing different genetically engineered mouse models, we found that expression of Lrp1 is essen...

[3-3H] sphingosine-1-phosphate
Sphingosine-1-phosphate (d17:1)
Sphingosine-1-phosphate (d16:1)
n-octanoylsphingosine-1-phosphate
Sphingosine-1-phosphate-d7 (d18:1)
N,N-dimethylsphingosine-1-phosphate
4,4',4''-(1H-Imidazole-2,4,5-triyl)tribenzonitrile
Citicoline sodium salt sesquihydrate
(R)-2-((tert-Butoxycarbonyl)amino)-3-(4-chloro-3-hydroxyphenyl)propanoic acid
Rel-benzyl (3aS,6aR)-3a-hydroxy-5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
2-((tert-Butoxycarbonyl)amino)-3-(2-chloro-3,6-difluorophenyl)propanoic acid
Ethyl (1R,2R)-1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylate hydrochloride
3,6-diamino-9-(2-carboxy-4-((6-(4-(4-((2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)amino)-4-oxobutyl)-1H-1,2,3-triazol-1-yl)hexyl)carbamoyl)phenyl)-5-sulfoxanthylium-4-sulfonate
Methyl 3-amino-3-(5-chloro-4-fluoro-2-methoxyphenyl)propanoate
(R)-7-(Pyrrolidin-2-yl)quinoline
(S)-2-((tert-Butoxycarbonyl)amino)-3-(3-hydroxy-2-methylphenyl)propanoic acid

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