3-(Trifluoromethyl)-s-triazolo[3,4-a]isoquinoline

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Names

[ CAS No. ]:
27022-50-0

[ Name ]:
3-(Trifluoromethyl)-s-triazolo[3,4-a]isoquinoline

[Synonym ]:
3-Trifluormethyl-s-triazolo<3,4-a>isochinolin
NC 1140

Chemical & Physical Properties

[ Density]:
1.49g/cm3

[ Molecular Formula ]:
C11H6F3N3

[ Molecular Weight ]:
237.18100

[ Exact Mass ]:
237.05100

[ PSA ]:
30.19000

[ LogP ]:
2.90130

[ Index of Refraction ]:
1.621

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XZ5479500
CHEMICAL NAME :
s-Triazolo(3,4-a)isoquinoline, 3-(trifluoromethyl)-
CAS REGISTRY NUMBER :
27022-50-0
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C11-H6-F3-N3
MOLECULAR WEIGHT :
237.20
WISWESSER LINE NOTATION :
T B566 CNN FNJ EXFFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
660 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 212,205,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
487 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3873705
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
720 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 212,205,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
440 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3873705

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[3,4-a]isoquinoline
  • 8,9-dimethoxy-[1,2,4]triazolo[3,4-a]isoquinoline
  • 3-Hydrazino-s-triazolo [3,4-a] phthalazine
  • 3-HYDROXYMETHYL-S-TRIAZOLO[3,4-A]PHTHALAZINE
  • 3-methyl-[1,2,4]triazolo[3,4-a]isoquinoline
  • 3-methylsulfanyl-[1,2,4]triazolo[3,4-a]isoquinoline
  • 2-[(4-Chloro-3-methylphenyl)methyl]cyclopentan-1-amine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • (2S,4S)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-(1-methylethyl)-4-[(2S,4S)-tetrahydro-4-(1-methylethyl)-5-oxo-2-furanyl]butyl methyl carbonate
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 4'-Azaspiro[azetidine-2,2'-bicyclo[2.2.2]octane]
  • 2-{4-[2-cyclopropyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetyl]thiomorpholin-3-yl}acetic acid
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide