5-Fluorotryptamine hydrochloride

Names

[ Name ]:
5-Fluorotryptamine hydrochloride

[Synonym ]:
5-Fluorotryptaminehydrochloride
2-(5-Fluoro-1H-indol-3-yl)ethanamine
1H-Indole-3-ethanamine, 5-fluoro-, monohydrochloride (9CI)
1H-Indole-3-ethanamine, 5-fluoro-
1H-Indole-3-ethanamine, 5-fluoro-, hydrochloride (1:1)
5-Fluorotryptamine hydrochloride
2-(5-fluoro-1H-indol-3-yl)ethanamine,hydrochloride
EINECS 220-307-5
MFCD00051081
2-(5-Fluoro-1H-indol-3-yl)ethanamine hydrochloride (1:1)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
346.0±27.0 °C at 760 mmHg

[ Melting Point ]:
277-283

[ Molecular Formula ]:
C₁₀H₁₂ClFN₂

[ Molecular Weight ]:
214.667

[ Flash Point ]:
163.0±23.7 °C

[ Exact Mass ]:
214.067307

[ PSA ]:
41.81000

[ LogP ]:
1.52

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.644

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL4055600

CHEMICAL NAME :: Indole, 3-(2-aminoethyl)-5-fluoro-, hydrochloride

CAS REGISTRY NUMBER :: 2711-58-2

LAST UPDATED :: 199206

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H11-F-N2.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 529 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 16,200,1960

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NL4055600

[ HS Code ]:
2942000000

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2942000000

Articles

5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function.

Eur. J. Pharmacol. 580(3) , 291-7, (2008)

Antagonists, but not agonists, of the 5-HT3 receptor are useful therapeutic agents, and it is possible that partial agonists may also be potentially useful in the clinic. Here we show that 5-fluorotry...

Quantitative determination of melatonin in human plasma and cerebrospinal fluid with high-performance liquid chromatography and fluorescence detection.

Biomed. Chromatogr. 14(5) , 306-10, (2000)

A validated new and precise reversed-phase high-performance liquid chromatographic method for the determination of melatonin in human plasma and cerebrospinal fluid, with 5-fluorotryptamine as interna...

Thrombin: active-site topography.

Ann. N. Y. Acad. Sci. 485 , 80-95, (1986)