3,5-Difluorophenol

Names

[ Name ]:
3,5-Difluorophenol

[Synonym ]:
Phenol, 3,5-difluoro-
3,5-difluoro phenol
3,5-difiuorophenol
QR CF EF
Phenol,3,5-difluoro
3,5-fluorophenol
3,5-difluorphenol
3,5-Diflourophenol
3,5-Difluorophenol
MFCD00002255

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
175.4±20.0 °C at 760 mmHg

[ Melting Point ]:
54-57 °C(lit.)

[ Molecular Formula ]:
C₆H₄F₂O

[ Molecular Weight ]:
130.092

[ Flash Point ]:
70.6±0.0 °C

[ Exact Mass ]:
130.023026

[ PSA ]:
20.23000

[ LogP ]:
2.42

[ Vapour Pressure ]:
0.9±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.496

[ Storage condition ]:
Flammables area

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R11;R20/21/22;R34

[ Safety Phrases ]:
S26-S36-S45-S36/37/39-S16

[ RIDADR ]:
UN 1325 4.1/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
29081000

Precursor & DownStream

Precursor

DownStream

2-Bromo-3,5-difluorophenol
1,5-Difluoro-3-methoxy-2-nitrobenzene
1,3-Difluoro-5-methoxybenzene
2,4-Difluoro-6-hydroxybenzaldehyde
2,6-Difluoro-4-methoxybenzoic acid
1-(Benzyloxy)-3,5-difluorobenzene
2,6-Difluoro-4-methoxyaniline
2,4-difluoro-6-hydroxybenzoic acid
3,5-Difluoro-2-nitrophenol
1-Butoxy-3,5-difluorobenzene

Customs

[ HS Code ]: 2908199090

[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%

Articles

Analysis of the association of cobalt(III) chelates with fluorine-containing phenols in supercritical carbon dioxide.

Talanta 146 , 789-94, (2015)

The solubilities of several cobalt(III) chelates (CoL3) with in supercritical carbon dioxide (SC-CO2) were investigated in the presence of fluorine- and trifluoromethyl-substituted phenols (PhOH) usin...

Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).

Bioorg. Med. Chem. Lett. 18 , 1583-7, (2008)

The inhibition of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) with three phenols was investigated. Phenol was an effective CA I-IV, IX, XII and XIV inhibitor (K(I)s of 2.7-11.5 microM) and a...

A convenient synthesis of 4-alkoxy-and 4-hydroxy-2, 6-difluoroanilines. Alonso-Alija C, et al.

Tetrahedron Lett. 45(1) , 95-98, (2004)