4-Azaindole

Names

[ CAS No. ]:
272-49-1

[ Name ]:
4-Azaindole

[Synonym ]:
PYRROLOPYRIDINE
MFCD00971977
1,4-Diazaindene
1h-pyrrolo[3,2-b]pyridine 4-oxide
4-Azaindole
1H-Pyrrolo[3,2-b]pyridine
4-azanidole

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
273.8±13.0 °C at 760 mmHg

[ Melting Point ]:
126-127ºC

[ Molecular Formula ]:
C₇H₆N₂

[ Molecular Weight ]:
118.14

[ Flash Point ]:
124.8±11.1 °C

[ Exact Mass ]:
118.053101

[ PSA ]:
28.68000

[ LogP ]:
0.78

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.697

[ Storage condition ]:
2~8℃

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY8715000

CHEMICAL NAME :: 1H-Pyrrolo(3,2-b)pyridine

CAS REGISTRY NUMBER :: 272-49-1

BEILSTEIN REFERENCE NO. :: 0109683

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H6-N2

MOLECULAR WEIGHT :: 118.15

WISWESSER LINE NOTATION :: T56 BM FNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,480,1963

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
41

[ Safety Phrases ]:
26-39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
29339980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-(3-nitropyridin-2-yl)acetonitrile
(2-trimethylsilanylethynylpyridin-3-yl) carbamic acid tert-butyl ester
N,N-dimethyl-2-(3-nitropyridin-2-yl)ethenamine
(2-Trimethylsilanylethynyl-pyridin-3-yl)carbamic acid ethyl ester
TERT-BUTYL (2-METHYLPYRIDIN-3-YL)CARBAMATE
N,N-Dimethylformamide
3-NITRO-2-VINYLPYRIDINE
2-Chloro-3-nitropyridine
1H-Pyrrolo[3,2-b]pyridine, 1-acetyl- (8CI)
2-Methyl-3-nitropyridine

DownStream

6-Chloro-7-azaindole
7-Azaindole-7-oxide
methyl 6-iodopyrrolo[2,3-b]pyridine-1-carboxylate
1-Boc-3-bromo-1H-pyrrolo[3,2-b]pyridine
N,N-dimethyl-1-(1H-pyrrolo[3,2-b]pyridin-3-yl)methanamine
3-Bromo-1H-pyrrolo[3,2-b]pyridine
6-Methyl-7-azaindole
1H-Pyrrolo[3,2-b]pyridine-3-carbaldehyde
3-Bromo-6-methyl-1H-pyrrolo[2,3-b]pyridine
1H-Pyrrolo[3,2-b]pyridine 4-oxide

Customs

[ HS Code ]: 29339980

Articles

Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding Mode.

PLoS ONE 10 , e0142711, (2015)

Combined fatty acid amide hydrolase (FAAH) and cyclooxygenase (COX) inhibition is a promising approach for pain-relief. The Flu-AM1 and Ibu-AM5 derivatives of flurbiprofen and ibuprofen retain similar...

2-Iodo-4-azaindole
6-Cyano-4-azaindole
6-Bromo-4-azaindole
5-Bromo-4-azaindole
5-AMINO-4-AZAINDOLE
5-Chloro-4-azaindole
2-[(3-Bromo-6-chloro-2-pyridinyl)amino]ethanol
(1-tetrahydropyran-2-yl-6,7-dihydro-4H-pyrano[4,3-c]pyrazol-3-yl)boronic acid
Tert-butyl 3-(4-cyclopropyl-1,3-thiazol-5-yl)piperazine-1-carboxylate
(2R)-2-amino-4-methoxy-5-methylhexanoic acid
6-(Difluoromethyl)-N2-[2-(phenylmethyl)cyclopentyl]-1,3,5-triazine-2,4-diamine
2-(1-Methylcyclopropoxy)ethan-1-amine
(3S)-3-(3-fluoro-2-methylphenyl)-3-hydroxypropanoic acid
Methyl 2-[[[2-[(3-chlorophenyl)amino]-2-oxoethyl]methylamino]sulfonyl]benzoate
Benzenepropanoic acid, I(2)-amino-3-bromo-5-carboxy-I+/--hydroxy-I+/--methyl-, (I+/-R,I(2)R)-
Acetamide, N,Na(2)-[1H-pyrrole-2,5-diylbis(methylidynenitrilo-2,1-phenylene)]bis-

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