6-Hydroxy-L-DOPA

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Names

[ Name ]:
6-Hydroxy-L-DOPA

[Synonym ]:
L-Hydroxydopa
2,4,5-trihydroxyphenyl-L-alanine
2,4,5-trihydroxy-L-phenylalanine
2,5-Dihydroxy-L-tyrosine
2,5-Dihydroxy-L-tyrosine 3-(2,4,5-Trihydroxyphenyl)-L-alanine
L-6-Hydroxydopa
(2S)-2-amino-3-(2,4,5-trihydroxyphenyl)propanoic acid
2,4,5,-trihydroxyphenylalanine
2,4,5-Trihydroxyphenylalanine,L
6-OH-DOPA
L-2,4,5-Trihydroxyphenylalanine
6-Hydroxydopa

Chemical & Physical Properties

[ Density]:
1.606g/cm3

[ Boiling Point ]:
515.2ºC at 760mmHg

[ Molecular Formula ]:
C₉H₁₁NO₅

[ Molecular Weight ]:
213.19

[ Flash Point ]:
265.4ºC

[ Exact Mass ]:
213.06400

[ PSA ]:
124.01000

[ LogP ]:
0.45810

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY7640000

CHEMICAL NAME :: Alanine, 3-(2,4,5-trihydroxyphenyl)-, L-

CAS REGISTRY NUMBER :: 27244-64-0

LAST UPDATED :: 199206

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H11-N-O5

MOLECULAR WEIGHT :: 213.21

WISWESSER LINE NOTATION :: QVYZ1R BQ DQ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 100 mg/kg

SEX/DURATION :: female 17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 17,987,1975

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2922509090

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

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FEBS Lett. 380(1-2) , 183-7, (1996)

Resonance Raman spectra were obtained of the free radical site in substrate reduced anaerobic samples of pea seedling copper amine oxidase (PSAO). The spectra differ significantly from those reported ...

Adenosine A2A receptor antagonists improve deficits in initiation of movement and sensory motor integration in the unilateral 6-hydroxydopamine rat model of Parkinson's disease.

Synapse 61 , 606-614, (2007)

Evidence obtained in rodent and primate models of Parkinson's disease (PD) and preliminary clinical trials, indicates that adenosine A(2A) receptor antagonists might represent a promising nondopaminer...

Up-regulation in expression of vesicular glutamate transporter 3 in substantia nigra but not in striatum of 6-hydroxydopamine-lesioned rats.

Neurosignals 15(5) , 238-48, (2006)

Overactivity of the glutamatergic system is suggested to be closely related to the onset and pathogenesis of Parkinson's disease. Vesicular glutamate transporters (VGLUT1, T2 and T3) are a group of gl...