N-Desethyl Metoclopramide

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Names

[ CAS No. ]:
27260-19-1

[ Name ]:
N-Desethyl Metoclopramide

[Synonym ]:
ethylethylenediamine-4-amino-5-chloro-2-methoxybenzoic acid amide
N-deethyl-Metoclopramide

Chemical & Physical Properties

[ Density]:
1.2g/cm3

[ Boiling Point ]:
414.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₈ClN₃O₂

[ Molecular Weight ]:
271.74300

[ Flash Point ]:
204.5ºC

[ Exact Mass ]:
271.10900

[ PSA ]:
79.87000

[ LogP ]:
2.81700

[ Vapour Pressure ]:
4.41E-07mmHg at 25°C

[ Index of Refraction ]:
1.559

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ3330000

CHEMICAL NAME :: o-Anisamide, 4-amino-5-chloro-N-(2-(ethylamino)ethyl)-

CAS REGISTRY NUMBER :: 27260-19-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H18-Cl-N3-O2

MOLECULAR WEIGHT :: 271.78

WISWESSER LINE NOTATION :: 2M2MVR DZ CG FO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 242 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 115,649,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 115,649,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 245 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 115,649,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 115,649,1976

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

N-Ethylethylenediamine
4-Amino-5-Chloro-2-Methoxybenzoic Acid
metoclopramide
metoclopramide N-oxide

DownStream

Related Compounds

N-Desethyl etifoxine-d5
N-Desethyl amodiaquine dihydrochloride
N-Desethyl rac-Benzilonium
N-DESETHYL VARDENAFIL-D8
N-Desethyl Milnacipran
N-desethyl Amodiaquine
tert-butyl N-[(1R)-1-(5-chloropyridin-2-yl)-3-oxopropyl]carbamate
N-{2-azaspiro[4.4]nonan-6-yl}-2-nitrobenzene-1-sulfonamide
5-Bromo-6-ethyl-2-(propan-2-yl)imidazo[2,1-b][1,3]thiazole
1-[2-(1H-indazol-7-yl)propan-2-yl]cyclopropan-1-amine
N-{2-[2-(methylamino)ethoxy]ethyl}-2-nitrobenzene-1-sulfonamide
N-(6,6-dimethylazepan-4-yl)-2-nitrobenzene-1-sulfonamide
3-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)but-2-ynoyl]-2-methyl-1,3-thiazolidine-4-carboxylic acid
N-{6-azabicyclo[3.2.1]octan-3-yl}-2-nitrobenzene-1-sulfonamide
N-[(3-fluoroazetidin-3-yl)methyl]-4-nitrobenzene-1-sulfonamide
1-(2-nitrobenzenesulfonyl)-2,3-dihydro-1H-indol-7-amine

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