Dimefline Hydrochloride

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Names

[ CAS No. ]:
2740-04-7

[ Name ]:
Dimefline Hydrochloride

[Synonym ]:
dimefline hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
465.3ºC at 760 mmHg

[ Molecular Formula ]:
C20H22ClNO3

[ Molecular Weight ]:
359.84700

[ Flash Point ]:
235.2ºC

[ Exact Mass ]:
359.12900

[ PSA ]:
42.68000

[ LogP ]:
4.64060

[ Vapour Pressure ]:
7.81E-09mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LK8575000
CHEMICAL NAME :
Flavone, 8-((dimethylamino)methyl)-7-methoxy-3-methyl-, hydrochloride
CAS REGISTRY NUMBER :
2740-04-7
LAST UPDATED :
199009
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C20-H21-N-O3.Cl-H
MOLECULAR WEIGHT :
359.88
WISWESSER LINE NOTATION :
T66 BO EVJ CR& D1 IO1 J1N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,345,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 24,1239,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 128,176,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 128,176,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 128,176,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1480 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,263,1964

Safety Information

[ Risk Phrases ]:
20/21/22

Related Compounds

  • Tyrocidine, hydrochloride
  • Triprolidine hydrochloride
  • Minoxidil hydrochloride
  • Elacridar hydrochloride
  • dodecylamine hydrochloride
  • Azetidine, hydrochloride, homopolymer (9CI)
  • 4-(aminomethyl)-N-cyclobutyl-4-methylcyclohexan-1-amine
  • 1-[4-(2,6-Diethylmorpholin-4-yl)butyl]cyclobutane-1-carbonitrile
  • (9H-fluoren-9-yl)methyl (3R,5R)-3-(tert-butoxy)-5-hydroxypiperidine-1-carboxylate
  • rac-(3R,4S)-4-(2-methoxy-5-methylphenyl)-3-methylpyrrolidin-3-amine
  • (9H-fluoren-9-yl)methyl 2-cyclopropyl-4-hydroxy-5H,6H,7H-pyrrolo[3,4-d]pyrimidine-6-carboxylate
  • 2-[1-(3,4-dimethoxyphenyl)-5,6-dimethoxy-1H-1,3-benzodiazol-2-yl]ethan-1-amine dihydrochloride
  • benzyl N-{3-hydroxy-4-[(prop-2-en-1-yl)carbamoyl]phenyl}carbamate
  • (9H-fluoren-9-yl)methyl N-ethyl-N-[(2S)-2-hydroxypropyl]carbamate
  • 5-{4H,5H,6H,7H-pyrazolo[1,5-a]pyrazin-3-yl}thiophene-2-carbonitrile
  • Benzyl 8-bromo-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylate
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