1-(bis(4-fluorophenyl)methyl)piperazine

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Names

[ CAS No. ]:
27469-60-9

[ Name ]:
1-(bis(4-fluorophenyl)methyl)piperazine

[Synonym ]:
N-[bis(4-fluorophenyl)methyl]piperazine
1-(4,4'-Difluorodiphenylmethyl)piperazine
4,4'-Difluorobenzhydrylpiperazine
1-[Bis-(4-fluorophenyl)methyl]piperazine
1-[(4',4''-difluorodiphenyl)methyl]piperazine
MFCD00038660
1 [bis(4-Fluorophenyl)methyl]-piperazine
1-[Bis(4-fluorophenyl)methyl]piperazine
1-(4,4'-Difluorobenzhydryl)piperazine
1-(bis(4-fluorophenyl)methyl)piperazine
[bis(4-fluorophenyl)methyl]piperazine
1-Bis(4-fluorophenyl)methyl piperazine
Piperazine, 1-[bis(4-fluorophenyl)methyl]-
1-[bis-(p-fluorophenyl)methyl]piperazine
EINECS 248-476-0

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
367.9±37.0 °C at 760 mmHg

[ Melting Point ]:
88-92 °C(lit.)

[ Molecular Formula ]:
C17H18F2N2

[ Molecular Weight ]:
288.335

[ Flash Point ]:
176.3±26.5 °C

[ Exact Mass ]:
288.143799

[ PSA ]:
15.27000

[ LogP ]:
2.95

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.560

[ Water Solubility ]:
0.34 g/L (20 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R25;R36/37/38

[ Safety Phrases ]:
S26-S45-S36/37/39

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
I; II; III

[ Hazard Class ]:
6.1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Piperazine
  • 4,4'-Difluorodiphenylmethylchloride
  • 4,4'-Diflurobenzylmethanol
  • 4,4′-difluorobenzophenone
  • piperazine dihydrochloride
  • 1,1'-(Bromomethylene)bis(4-fluorobenzene)

DownStream

  • 1-[bis(4-fluorophenyl)methyl]-4-[3-(2,4-dimethoxyphenyl)prop-2-enyl]piperazine,but-2-enedioic acid
  • 1-benzylsulfanyl-3-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]propan-2-ol
  • Flunarizine
  • almitrine
  • 1-[bis(4-fluorophenyl)methyl]-4-[(2,4-dimethoxyphenyl)methyl]piperazine,dihydrochloride
  • Lomerizine hydrochloride

Articles

Oxidative metabolism of flunarizine in rat liver microsomes.

Res. Commun. Chem. Pathol. Pharmacol. 78(1) , 85-95, (1992)

The oxidative metabolism of flunarizine [1-[bis(4-fluorophenyl)-methyl]-4-(3-phenyl-2-propenyl)piperazine, FZ] to 1-[bis-(4-fluorophenyl)methyl]piperazine (M-1), 1-[bis(4-fluorophenyl)methyl]-4-[3-(4'...

Lipidosis of the dorsal root ganglia in rats treated with an almitrine metabolite.

Arch. Toxicol. 69(6) , 391-6, (1995)

Toxic effects of a detriazinyl metabolite of almitrine (DTMA) were evaluated in rats and on cultured rat macrophages. In rats daily treated with DTMA for 16 weeks, spastic gaits with heel-lifting appe...


More Articles

Related Compounds

  • N-(BIS(4-FLUOROPHENYL)METHYL)PIPERAZINE DIHYDROCHLORIDE
  • 1-(Bis(4-fluorophenyl)methyl)-4-(4-nitrophenyl)piperazine
  • 1-[BIS(4-FLUOROPHENYL)METHYL]-4-(4-NITROBENZYL)PIPERAZINE
  • 1-[bis(4-fluorophenyl)methyl]-4-[(3,4-dichlorophenyl)methyl]piperazine
  • 1-[bis(4-fluorophenyl)methyl]-4-[(2,4-dimethoxyphenyl)methyl]piperazine,dihydrochloride
  • 1-[bis(4-fluorophenyl)methyl]-4-(3-phenylprop-2-enyl)piperazine
  • N-(1H-indol-5-yl)-1-(propan-2-yl)-1H-indole-6-carboxamide
  • N-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2,2-diphenylacetamide
  • N-[3-Hydroxy-4-(hydroxymethyl)cyclopentyl]-3,3-diphenylpropanamide
  • N-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)thiophene-2-carboxamide
  • (S)-2-((1R,5R)-8-oxo-2,3,4,5,6,8-hexahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocine-3-carboxamido)-2-phenylacetic acid
  • 2,3,4,6,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-7-one
  • 5-cyclopropyl-N-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)isoxazole-3-carboxamide
  • 2,2-dimethyl-N-[(2R)-oxiran-2-ylmethyl]propanamide
  • (3S)-3-amino-3-(4-fluorophenyl)propanamide hydrochloride
  • 2-Amino-3-methoxy-2-methylpropanoic acid hydrochloride
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