7-Acetoxy-4-methylcoumarin

Suppliers

Names

[ Name ]:
7-Acetoxy-4-methylcoumarin

[Synonym ]:
4-Methylumbeliferyl acetate
4-Methylumbelliferyl Acetate
7-Aceoxy-4-MethylcouMarin
EINECS 220-386-6
MUB ACETATE
acetic acid 4-methyl-2-oxo-2H-chromen-7-yl ester
7-Acetoxy-4-methylcoumarin
7-ACETYL-4-METHYLCOUMARIN
MUACETATE
4-METHYL-7-ACETOXYCOUMARIN
4-methyl-2-oxo-2H-chromen-7-yl acetate
METHYLUMBELLIFERYL ACETATE
7-acetoxy-4-methyl-chromen-2-one
MFCD00006865

Chemical & Physical Properties

[ Density]:
1.263g/cm3

[ Boiling Point ]:
371.4ºC at 760mmHg

[ Melting Point ]:
149-150 °C(lit.)

[ Molecular Formula ]:
C₁₂H₁₀O₄

[ Molecular Weight ]:
218.20500

[ Flash Point ]:
191.5ºC

[ Exact Mass ]:
218.05800

[ PSA ]:
56.51000

[ LogP ]:
2.02670

[ Vapour Pressure ]:
8.68E-06mmHg at 25°C

[ Index of Refraction ]:
1.588

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2932209090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Methylumbelliferone
Ethanoic anhydride
acetic acid
Acetyl chloride
Resorcine
Resorcinol (monoacetate)
Ethyl acetoacetate
2,4-Dihydroxyacetophenone

DownStream

methyl 3-amino-2-cyano-3-iodoprop-2-enoate
6-Acetyl-7-hydroxy-4-methyl-2H-chromen-2-one
8-Acetyl-7-hydroxy-4-methyl-chromen-2-one
8-acetyl-7-hydroxycoumarin
2H-1-Benzopyran-2-one, 8-benzoyl-7-hydroxy
2',4'-Dimethylacetophenone
4-Methylumbelliferone
acetic acid
4-methyl-2-sulfanylchromen-7-one

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Automated carboxylesterase assay for the evaluation of ionic liquids' human toxicity.

J. Hazard. Mater. 244-245 , 563-9, (2013)

Aiming the prediction of ionic liquids' (ILs) human toxicity, an automated carboxylesterase activity assay was developed. The method was implemented on a sequential injection analysis (SIA) system and...

Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.

J. Med. Chem. 48 , 2906-15, (2005)

Carboxylesterases (CE) are ubiquitous enzymes responsible for the metabolism of xenobiotics. Because the structural and amino acid homology among esterases of different classes, the identification of ...

Comparison of xenobiotic metabolizing enzyme activities in ex vivo human skin and reconstructed human skin models from SkinEthic.

Arch. Toxicol. 88(9) , 1681-1694, (2014)

Skin function is not limited to a physical barrier. According to its total surface area, it is also considered as an extra-hepatic metabolizing organ. In vitro engineered human skins have been develop...