Vildagliptin (LAF-237)

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Names

[ CAS No. ]:
274901-16-5

[ Name ]:
Vildagliptin (LAF-237)

[Synonym ]:
2-Pyrrolidinecarbonitrile, 1-[2-[(3-hydroxytricyclo[3.3.1.1]dec-1-yl)amino]acetyl]-, (2S)-
Galvus
(-)-(2S)-1-[[(3-Hydroxytricyclo[3.3.1.1[3,7]]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile
Vildagliptin
Laf 237
(2S)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]pyrrolidine-2-carbonitrile
(2S)-1-[N-(3-hydroxytricyclo[3.3.1.1]dec-1-yl)glycyl]pyrrolidine-2-carbonitrile
Unii-I6B4B2U96p
(2S)-1-[N-(3-Hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile

Chemical & Physical Properties

[ Density]:
1.27 g/cm3

[ Boiling Point ]:
531.3ºC at 760 mmHg

[ Melting Point ]:
153-155?C

[ Molecular Formula ]:
C17H25N3O2

[ Molecular Weight ]:
303.39900

[ Flash Point ]:
275.1ºC

[ Exact Mass ]:
303.19500

[ PSA ]:
76.36000

[ LogP ]:
1.50308

[ Storage condition ]:
-20°C Freezer

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-Amino-1-hydroxyadamantane
  • (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile
  • N-acetic acid-1-amino-3-adamantanol
  • (S)-pyrrolidine-2-carbonitrile
  • L-Prolinamide
  • 1-(Chloroacetyl)-L-prolinamide
  • 1-[N-formyl-N-(3-hydroxy-1-adamantyl)aminoacetyl]pyrrolidine-2-nitrile
  • Proline
  • 1-(Chloroacetyl)-L-proline
  • 1-Adamantanamine hydrochloride

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • vildagliptin Impurity Q
  • Vildagliptin-d7
  • Vildagliptin
  • Vildagliptin Impurity L
  • Vildagliptin impurity M
  • Vildagliptin Impurity ZA6
  • 2-[3-(4-tert-Butylphenyl)phenyl]ethan-1-amine
  • 2-{[(1-ethyl-1H-pyrazol-5-yl)methyl]amino}-2-methylpropan-1-ol
  • 2,6-dimethyl-N-(2-methylpropyl)oxan-4-amine
  • 5-[(Z)-[6-[(2-fluoro-4-methoxybenzoyl)carbamoylamino]-2-oxo-1H-indol-3-ylidene]methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide
  • N-Butyl-2,6-dimethyloxan-4-amine
  • N-[2-(diethylamino)ethyl]-5-[(Z)-[6-[(2-fluoro-4-methoxybenzoyl)carbamoylamino]-2-oxo-1H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • [5-(4-Hydroxyphenyl)-1H-imidazol-2-yl](3,4,5-trimethoxyphenyl)methanone
  • Phenyl[5-(3,4,5-trimethoxyphenyl)-1H-imidazol-2-yl]methanone
  • 3-(2-(7-(2-Chlorophenyl)-1,4-thiazepan-4-yl)-2-oxoethyl)oxazolidin-2-one
  • 2-Fluoro-N-[1-(2-propan-2-yloxyethyl)piperidin-4-yl]pyridine-4-carboxamide
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