TROLEANDOMYCIN
Suppliers
Names
[ CAS No. ]:
2751-09-9
[ Name ]:
TROLEANDOMYCIN
[Synonym ]:
tao
TRIACETYLOLEANDOMYCIN
TROLEANDOMYCIN
Taocin
evramicina
cyclamycin
Tri-O-acetyl-oleandomycin
EINECS 220-392-9
Mathromycin T
OLEANDOMYCIN TRIACETATE
Chemical & Physical Properties
[ Density]:
1.19g/cm3
[ Boiling Point ]:
812.5ºC at 760mmHg
[ Melting Point ]:
170 °C (lit.)
[ Molecular Formula ]:
C41H67NO15
[ Molecular Weight ]:
813.96800
[ Flash Point ]:
445.2ºC
[ Exact Mass ]:
813.45100
[ PSA ]:
184.19000
[ LogP ]:
3.62090
[ Vapour Pressure ]:
1.82E-26mmHg at 25°C
[ Index of Refraction ]:
1.515
[ Storage condition ]:
-20°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RJ9900000
- CHEMICAL NAME :
- Oleandomycin, triacetate (ester)
- CAS REGISTRY NUMBER :
- 2751-09-9
- LAST UPDATED :
- 199312
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C41-H67-N-O15
- MOLECULAR WEIGHT :
- 814.09
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Skin and Appendages - hair
- REFERENCE :
- ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,528,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 117 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia
- REFERENCE :
- ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,528,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,515,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 198 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,514,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 13650 mg/kg/13W-C
- TOXIC EFFECTS :
- Endocrine - changes in adrenal weight Blood - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 119,181,1993
Safety Information
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
36/37/38
[ Safety Phrases ]:
S22-S24/25
[ WGK Germany ]:
2
[ RTECS ]:
RJ9900000