Isoconazole

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Names

[ CAS No. ]:
27523-40-6

[ Name ]:
Isoconazole

[Synonym ]:
Travogyn
Isoconazol
1-[2-(2,4-Dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1H-imidazole
Travogen
1-{2-[(2,6-Dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
1-{2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}imidazole
fazol
Isoconazole
1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-
1-[2,4-Dichloro-b-[(2,6-dichlorobenzyl)oxy]phenethyl]imidazole
Isoconazolum

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
555.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H14Cl4N2O

[ Molecular Weight ]:
416.129

[ Flash Point ]:
289.5±30.1 °C

[ Exact Mass ]:
413.986023

[ PSA ]:
27.05000

[ LogP ]:
5.93

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.625

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Practically insoluble in water, very soluble in methanol, freely soluble in ethanol (96 per cent).

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NI4775700
CHEMICAL NAME :
1H-Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,6-dichlorophenyl)meth oxy)ethyl)-
CAS REGISTRY NUMBER :
27523-40-6
LAST UPDATED :
199303
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C18-H14-Cl4-N2-O
MOLECULAR WEIGHT :
416.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
189 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 13,195,1990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Bromo-2',4'-dichloroacetophenone
  • 2,2',4'-Trichloroacetophenone
  • 1-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOLE-1-YL) ETHANONE
  • 2-CHLORO-1-(2,4-DICHLOROPHENYL)ETHANOL
  • 1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol
  • α,2,6-Trichlorotoluene

DownStream

Articles

Tinea corporis of the shin and chest successfully treated with a topical antifungal and corticosteroid cream.

Mycoses 51 Suppl 4 , 34-6, (2008)

The effective use of isoconazole nitrate and diflucortolone valerate cream in the treatment of inguino-femoral skin fold mycosis.

Mycoses 51 Suppl 4 , 29-31, (2008)

Treatment of candidal intertrigo with a topical combination of isoconazole nitrate and diflucortolone valerate.

Mycoses 51 Suppl 4 , 42-3, (2008)


More Articles

Related Compounds

  • isoconazole
  • isoconazole
  • Isoconazole
  • Isoconazole nitrate
  • 4-(Difluoromethyl)-2-hydroxy-6-methylnicotinamide
  • 4-Amino-5-(fluoromethyl)-6-(trifluoromethoxy)picolinic acid
  • 3-Fluoro-2-iodo-6-(trifluoromethoxy)pyridin-4-amine
  • propan-2-yl N-(4-amino-3-methylbutan-2-yl)carbamate
  • 2-Cyclopentyl-2-fluoroacetamide
  • 2,4-Dimethylpentane-1-sulfonamide
  • 4-Isocyanato-3-nitrophenol
  • 3-(Difluoromethyl)-4,4-dimethylpentanoic acid
  • 1-Cyclobutyl-3,3-difluorocyclobutan-1-amine
  • 4-ethynyl-3,5-dimethyl-1-(propan-2-yl)-1H-pyrazole