D-1,4-dithiothreitol

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Names

[ CAS No. ]:
27565-41-9

[ Name ]:
D-1,4-dithiothreitol

[Synonym ]:
DITHIOERYTHRITOL
DTT
1,4-Dithiothreitol
L-(−)-Dithiothreitol
1,4-Bissulfanylbutane-2,3-diol
DL-1,4-Dimercapto-2,3-dihydroxybutane
2,3-Butanediol, 1,4-dimercapto-, (2S,3S)-
THREO-2,3-DIHYDROXY-1,4-DITHIOLBUTANE
(2R,3R)-(-)-2,3-Dihydroxy-1,4-butanedithiol
1,4-Disulfanyl-2,3-butanediol
Threitol, 1,4-dithio-
(R*,R*)-1,4-DIMERCAPTO-2,3-BUTANEDIOL
EINECS 222-468-7
L-Dithiothreitol
(2S,3S)-1,4-Disulfanyl-2,3-butanediol
Cleland's Reagent
(2S,3S)-1,4-Disulfanylbutane-2,3-diol
(2R*,3S*)-1,4-dimercaptobutane-2,3-diol
dithiothreitol
threo-2,3-Dihydroxy-1,4-butanedithiol
(2R*,3S*)-1,4-dimercapto-2,3-butanediol
Sputolysin
(2R,3R)-(-)-1,4-Dimercapto-2,3-butanediol
L-Cleland's
1,4-Disulfanylbutane-2,3-diol
2,3-Butanediol, 1,4-dimercapto-
MFCD00004877
(±)-1,4-Dimercapto-2,3-butanediol

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
364.5±42.0 °C at 760 mmHg

[ Melting Point ]:
41-44 °C(lit.)

[ Molecular Formula ]:
C4H10O2S2

[ Molecular Weight ]:
154.251

[ Flash Point ]:
174.2±27.9 °C

[ Exact Mass ]:
154.012222

[ PSA ]:
118.06000

[ LogP ]:
0.07

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.579

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XO8576500
CHEMICAL NAME :
Threitol, 1,4-dithio-, DL-
CAS REGISTRY NUMBER :
27565-41-9
BEILSTEIN REFERENCE NO. :
1719757
LAST UPDATED :
199806
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C4-H10-O2-S2
MOLECULAR WEIGHT :
154.26
WISWESSER LINE NOTATION :
SH1YQYQ1SH -DL, THREO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
169 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
333 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
94 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - rat Liver
DOSE/DURATION :
1 mmol/L
REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 166,400,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2950 No. of Facilities: 35 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 627 (estimated) No. of Female Employees: 436 (estimated)

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
25-36/37/38-22-20/21/22

[ Safety Phrases ]:
S26-S45

[ WGK Germany ]:
3

[ RTECS ]:
EK1610000

[ HS Code ]:
2930909090

Precursor & DownStream

Precursor

DownStream

  • (4S,5S)-dithiane-4,5-diol
  • mercaptoethanol
  • 2-(2-sulfanylethylsulfonyl)ethanethiol
  • TNB

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • D-1,4-dithiothreitol
  • 1,4-Bis[(2H)sulfanyl]-2,3-(2H6)butane(2H2)diol
  • IMidazo[1,2-d][1,4]benzoxazepine, 9-bromo-5,6-dihydro-2-[3-Methyl-1-(1-Methylethyl)-1H-1,2,4-triazol-5-yl]-
  • Pyrrolo[1,2-d][1,4]thiazepine (9CI)
  • Pyrazino[1,2-d][1,4]diazepine-1,9(2H,6H)-dione, 3,4,7,8-tetrahydro- (9CI)
  • 7H-ISOQUINO(2,1-d)(1,4)BENZODIAZEPIN-8-IUM, 9,10-DIHYDRO-6-(4-BIPHENYL YL)-3-CHLO
  • (1H-benzo[d]imidazol-5-yl)(3-(3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl)azetidin-1-yl)methanone
  • Benzo[c][1,2,5]thiadiazol-5-yl(3-(3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl)azetidin-1-yl)methanone
  • 2-[2-(Cyclohexylamino)benzimidazol-1-yl]acetic acid
  • 5-[1-(1-methyl-3-phenyl-1H-pyrazole-5-carbonyl)azetidin-3-yl]-3-(thiophen-2-yl)-1,2,4-oxadiazole
  • 3-(2-oxo-2-(3-(3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl)azetidin-1-yl)ethyl)quinazolin-4(3H)-one
  • (2-Methoxypyridin-3-yl)(3-(3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl)azetidin-1-yl)methanone
  • (3-Bromophenyl)(3-(3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl)azetidin-1-yl)methanone
  • (2,6-Difluorophenyl)(3-(3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl)azetidin-1-yl)methanone
  • (E)-1-(3-(3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl)azetidin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
  • 2-Phenoxy-1-(3-(3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl)azetidin-1-yl)ethanone
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