Tilorone dihydrochloride
Suppliers
Names
[ CAS No. ]:
27591-69-1
[ Name ]:
Tilorone dihydrochloride
[Synonym ]:
9H-Fluoren-9-one, 2,7-bis[2-(diethylamino)ethoxy]-, hydrochloride (1:2)
2,7-Bis-deae-fluorenone
2,7-Bis(2-(diethylamino)ethoxy)fluoren-9-one dihydrochloride
2,7-Bis(2-diethylaminoethoxy)fluoren-9-one dihydrochloride
bis-deae-fluorenonehydrochloride
TILORONE HYDROCHLORIDE
TILORONE 2HCL
2,7-Bis[2-(diethylamino)ethoxy]-9-fluorenone dihydrochloride
MFCD00134071
9H-Fluoren-9-one, 2,7-bis[2- (diethylamino)ethoxy]-, dihydrochloride
Tilorone DiHCl
Deae-f
2,7-Bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one dihydrochloride
UNII-BJ507J4LKY
Tilorone (dihydrochloride)
Chemical & Physical Properties
[ Density]:
1.102g/cm3
[ Boiling Point ]:
552.3ºC at 760 mmHg
[ Melting Point ]:
230-233 °C(lit.)
[ Molecular Formula ]:
C25H36Cl2N2O3
[ Molecular Weight ]:
483.471
[ Flash Point ]:
287.8ºC
[ Exact Mass ]:
482.210297
[ PSA ]:
42.01000
[ LogP ]:
5.94320
[ Vapour Pressure ]:
3.05E-12mmHg at 25°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LL9000000
- CHEMICAL NAME :
- Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-, dihydrochloride
- CAS REGISTRY NUMBER :
- 27591-69-1
- LAST UPDATED :
- 199606
- DATA ITEMS CITED :
- 17
- MOLECULAR FORMULA :
- C25-H34-N2-O3.2Cl-H
- MOLECULAR WEIGHT :
- 483.53
- WISWESSER LINE NOTATION :
- L B656 HVJ EO2N2&2 LO2N2&2 &GH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 4 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - anorexia (human) Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 852 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 244 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 145 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 53500 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 150 mg/kg/5D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 250 mg/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 400 mg/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetal death
MUTATION DATA
- TYPE OF TEST :
- DNA adduct
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- FEBLAL FEBS Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1968- Volume(issue)/page/year: 28,5,1972 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335-H351
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R20/21/22;R36/37/38;R40
[ Safety Phrases ]:
S7-S22-S26-S37/39
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
LL9000000
[ HS Code ]:
2922509090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2922509090
[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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