1,4-bis(2-isocyanatopropan-2-yl)benzene

Names

[ CAS No. ]:
2778-41-8

[ Name ]:
1,4-bis(2-isocyanatopropan-2-yl)benzene

[Synonym ]:
EINECS 220-473-9
p-Tetramethylxylylene diisocyanate

Chemical & Physical Properties

[ Density]:
1.01g/cm3

[ Boiling Point ]:
330.5ºC at 760mmHg

[ Molecular Formula ]:
C14H16N2O2

[ Molecular Weight ]:
244.28900

[ Flash Point ]:
135.5ºC

[ Exact Mass ]:
244.12100

[ PSA ]:
58.86000

[ LogP ]:
2.82840

[ Vapour Pressure ]:
0.000165mmHg at 25°C

[ Index of Refraction ]:
1.515

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CY8490000
CHEMICAL NAME :
Benzene, 1,4-bis(1-isocyanato-1-methylethyl)-
CAS REGISTRY NUMBER :
2778-41-8
LAST UPDATED :
199710
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C14-H16-N2-O2
MOLECULAR WEIGHT :
244.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,160,1992 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - incontinence
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,160,1992
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
220 mg/m3/4H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,160,1992
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,160,1992

Safety Information

[ HS Code ]:
2929109000

Customs

[ HS Code ]: 2929109000

[ Summary ]:
2929109000. other isocyanates. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • 1,4-bis(2-hydroperoxypropan-2-yl)benzene
  • 1,4-bis(2-methoxypropan-2-yl)benzene
  • 1,2-bis(2-isocyanatopropan-2-yl)benzene
  • 1,3-bis(2-isocyanatopropan-2-yl)benzene,2-ethyl-2-(hydroxymethyl)propane-1,3-diol
  • 1,3-bis(2-isocyanatopropan-2-yl)benzene,2-(2-hydroxyethoxy)ethanol,oxepan-2-one
  • 1-chloro-4-(2-isocyanatopropan-2-yl)benzene
  • Ethyl 2-(((benzyloxy)carbonyl)(methyl)amino)acetate
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide