5-fluoro-1-[(2R,4R)-4-(hydroxymethyl)-7,7-dimethyl-3,6,8-trioxabicyclo[3.3.0]oct-2-yl]pyrimidine-2,4-dione

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Names

[ CAS No. ]:
2797-17-3

[ Name ]:
5-fluoro-1-[(2R,4R)-4-(hydroxymethyl)-7,7-dimethyl-3,6,8-trioxabicyclo[3.3.0]oct-2-yl]pyrimidine-2,4-dione

[Synonym ]:
5-fluoro-1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4(1H,3H)dione
5-fluorouridine-2,3-isopropylidene derivative
5-Fluoro-2',3'-O-(1-methylethylidene)uridine
5-Fluoro-2',3'-isopropylideneuridine
5-fluoro-1-[(2R,4R)-4-(hydroxymethyl)-7,7-dimethyl-3,6,8-trioxabicyclo[3.3.0]oct-2-yl]pyrimidine-2,4-dione
5-Fluoro-2',3'-O-isopropylideneuridine

Chemical & Physical Properties

[ Density]:
1.54g/cm3

[ Melting Point ]:
196-198ºC

[ Molecular Formula ]:
C12H15FN2O6

[ Molecular Weight ]:
302.25600

[ Exact Mass ]:
302.09100

[ PSA ]:
102.78000

[ Index of Refraction ]:
1.585

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YU8051000
CHEMICAL NAME :
Uridine, 5-fluoro-2',3'-O-(1-methylethylidene)-
CAS REGISTRY NUMBER :
2797-17-3
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C12-H15-F-N2-O6
MOLECULAR WEIGHT :
302.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
725 umol/L
REFERENCE :
CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 43,3268,1978

Precursor & DownStream

Precursor

  • 5-Fluorouridine
  • 2,2-Dimethoxypropane
  • Acetone
  • 1,1-Dimethoxypropane
  • Uridine
  • 2',3'-O-isopropylidene-O2,5'-cyclouridine
  • Uridine,2',3',5'-tribenzoate
  • 2',3'-o-isopropylideneuridine

DownStream

  • Fosfluridine tidoxil
  • 5-Fluoro-6-iodouridine

Related Compounds

  • 3-Iodo-1-isobutyl-1H-pyrazole-4-carbaldehyde
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 2-Chloro-5-((3-(trifluoromethyl)phenyl)sulfonyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine