SB216763

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
598.1±50.0 °C at 760 mmHg

[ Melting Point ]:
287-288.6ºC(lit.)

[ Molecular Formula ]:
C₁₉H₁₂Cl₂N₂O₂

[ Molecular Weight ]:
371.217

[ Flash Point ]:
315.5±30.1 °C

[ Exact Mass ]:
370.027588

[ PSA ]:
51.10000

[ LogP ]:
4.79

[ Appearance of Characters ]:
orange

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.702

[ Storage condition ]:
−20°C

[ Water Solubility ]:
DMSO: 20 mg/mL, soluble

Click to get detail MSDS

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Lenticular mitoprotection. Part B: GSK-3β and regulation of mitochondrial permeability transition for lens epithelial cells in atmospheric oxygen.

Mol. Vis. 19 , 2451-67, (2013)

Loss of integrity of either the inner or outer mitochondrial membrane results in the dissipation of the mitochondrial electrochemical gradient that leads to mitochondrial membrane permeability transit...

Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome.

PLoS ONE 6(9) , e24648, (2011)

Traumatic brain injury (TBI) sets in motion cascades of biochemical changes that result in delayed cell death and altered neuronal architecture. Studies have demonstrated that inhibition of glycogen s...

Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death.

J. Neurochem. 77 , 94-102 , (2001)

The phosphatidylinositol 3-kinase (PI 3-kinase)/protein kinase B (PKB; also known as Akt) signalling pathway is recognized as playing a central role in the survival of diverse cell types. Glycogen syn...

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