Etidronic acid
Suppliers
Names
[ CAS No. ]:
2809-21-4
[ Name ]:
Etidronic acid
[Synonym ]:
(1-Hydroxyethane-1,1-diyl)diphosphonic acid
Etidronsaeure
Acetodiphosphonic acid
ethane-1-hydroxy-1,1-diphosphonic acid
MFCD00070585
1-hydroxyethane 1,1-diphosphonic acid
Hydroxyethanediphosphonic acid
EHDP
Phosphonic acid, (1-hydroxyethylidene)bis-
Osteoscan
(1-hydroxyethane-1,1-diyl)bis(phosphonic acid)
1-Hydroxyethylidenediphosphonic acid
1-Hydroxyethylidene-1,1-diphosphonic Acid
(1-hydroxy-1-phosphonoethyl)phosphonic acid
Didronel IV
ethane-1-hydroxy-1,1-bisphosphonic acid
acide etidronique
EINECS 220-552-8
Oxyethylidenediphosphonic acid
HEDP
1-Hydroxyeth
Etidronic acid monohydrate (HEDP)
DEQUEST 2010
Turpinal SL
Etidronic acid
(1-Hydroxy-1,1-ethanediyl)bis(phosphonic acid)
acidum etidronicum
Etidronate
1-Hydroxyethane-1,1-diphosphonic acid
acido etidronico
Chemical & Physical Properties
[ Density]:
2.1±0.1 g/cm3
[ Boiling Point ]:
578.8±60.0 °C at 760 mmHg
[ Melting Point ]:
198~199℃
[ Molecular Formula ]:
C2H8O7P2
[ Molecular Weight ]:
206.028
[ Flash Point ]:
303.8±32.9 °C
[ Exact Mass ]:
205.974518
[ PSA ]:
154.91000
[ LogP ]:
-3.54
[ Vapour Pressure ]:
0.0±3.6 mmHg at 25°C
[ Index of Refraction ]:
1.586
[ Stability ]:
Stable. Incompatible with strong oxidizing agents.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SZ8562100
- CHEMICAL NAME :
- Phosphonic acid, (1-hydroxyethylidene)di-
- CAS REGISTRY NUMBER :
- 2809-21-4
- BEILSTEIN REFERENCE NO. :
- 1789291
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C2-H8-O7-P2
- MOLECULAR WEIGHT :
- 206.04
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ACIEAY Angewandte Chemie, International Edition in English. (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.1- 1962- Volume(issue)/page/year: 14,94,1975 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 40 mg/kg
- SEX/DURATION :
- female 7 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- SIGAAE Shika Igaku. Odontology. (Osaka Shika Gakkai, 1-47 Kyobashi, Higashi-ku, Osaka 540, Japan) V.1- 1930- Volume(issue)/page/year: 50,879,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 200 mg/kg
- SEX/DURATION :
- female 7 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)
- REFERENCE :
- JODUA2 Journal of Osaka Dental University. (Osaka Dental Univ., 1-47, Kyobashi Higashi-ku, Osaka 540, Japan) V.1- 1967- Volume(issue)/page/year: 20,91,1986
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 200 mg/kg
- SEX/DURATION :
- female 7 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- JODUA2 Journal of Osaka Dental University. (Osaka Dental Univ., 1-47, Kyobashi Higashi-ku, Osaka 540, Japan) V.1- 1967- Volume(issue)/page/year: 19,87,1985
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 200 mg/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- SIGAAE Shika Igaku. Odontology. (Osaka Shika Gakkai, 1-47 Kyobashi, Higashi-ku, Osaka 540, Japan) V.1- 1930- Volume(issue)/page/year: 49,837,1986
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 200 mg/kg
- SEX/DURATION :
- female 13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 26(1),16A,1982
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 1400 mg/kg
- SEX/DURATION :
- female 11-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 22,47,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0985 No. of Facilities: 404 (estimated) No. of Industries: 10 No. of Occupations: 7 No. of Employees: 6655 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0985 No. of Facilities: 3273 (estimated) No. of Industries: 73 No. of Occupations: 46 No. of Employees: 44885 (estimated) No. of Female Employees: 3814 (estimated)
Safety Information
[ Symbol ]:
GHS05
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H290-H318
[ Precautionary Statements ]:
P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
37/38-41
[ Safety Phrases ]:
S26-S39
[ RIDADR ]:
UN 3265
[ WGK Germany ]:
2
[ RTECS ]:
SZ8562100
[ Packaging Group ]:
II
[ Hazard Class ]:
8
[ HS Code ]:
2931900090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2931900090
[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%
Articles
J. Sci. Ind. Res. 65(10) , 808, (2006)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...
Biochim. Biophys. Acta 1841(7) , 977-86, (2014)
2,3-Oxidosqualene is an intermediate in cholesterol biosynthesis and 2,3:22,23-dioxidosqualene act as the substrate for an alternative pathway that produces 24(S),25-epoxycholesterol which effects cho...
Drug Discov. Today 16 , 697-703, (2011)
Drug-induced liver injury (DILI) is a leading cause of drugs failing during clinical trials and being withdrawn from the market. Comparative analysis of drugs based on their DILI potential is an effec...