Etidronic acid

Suppliers

Names

[ Name ]:
Etidronic acid

[Synonym ]:
(1-Hydroxyethane-1,1-diyl)diphosphonic acid
Etidronsaeure
Acetodiphosphonic acid
ethane-1-hydroxy-1,1-diphosphonic acid
MFCD00070585
1-hydroxyethane 1,1-diphosphonic acid
Hydroxyethanediphosphonic acid
EHDP
Phosphonic acid, (1-hydroxyethylidene)bis-
Osteoscan
(1-hydroxyethane-1,1-diyl)bis(phosphonic acid)
1-Hydroxyethylidenediphosphonic acid
1-Hydroxyethylidene-1,1-diphosphonic Acid
(1-hydroxy-1-phosphonoethyl)phosphonic acid
Didronel IV
ethane-1-hydroxy-1,1-bisphosphonic acid
acide etidronique
EINECS 220-552-8
Oxyethylidenediphosphonic acid
HEDP
1-Hydroxyeth
Etidronic acid monohydrate (HEDP)
DEQUEST 2010
Turpinal SL
Etidronic acid
(1-Hydroxy-1,1-ethanediyl)bis(phosphonic acid)
acidum etidronicum
Etidronate
1-Hydroxyethane-1,1-diphosphonic acid
acido etidronico

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
578.8±60.0 °C at 760 mmHg

[ Melting Point ]:
198~199℃

[ Molecular Formula ]:
C₂H₈O₇P₂

[ Molecular Weight ]:
206.028

[ Flash Point ]:
303.8±32.9 °C

[ Exact Mass ]:
205.974518

[ PSA ]:
154.91000

[ LogP ]:
-3.54

[ Vapour Pressure ]:
0.0±3.6 mmHg at 25°C

[ Index of Refraction ]:
1.586

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ8562100

CHEMICAL NAME :: Phosphonic acid, (1-hydroxyethylidene)di-

CAS REGISTRY NUMBER :: 2809-21-4

BEILSTEIN REFERENCE NO. :: 1789291

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C2-H8-O7-P2

MOLECULAR WEIGHT :: 206.04

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ACIEAY Angewandte Chemie, International Edition in English. (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.1- 1962- Volume(issue)/page/year: 14,94,1975 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 40 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: SIGAAE Shika Igaku. Odontology. (Osaka Shika Gakkai, 1-47 Kyobashi, Higashi-ku, Osaka 540, Japan) V.1- 1930- Volume(issue)/page/year: 50,879,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)

REFERENCE :: JODUA2 Journal of Osaka Dental University. (Osaka Dental Univ., 1-47, Kyobashi Higashi-ku, Osaka 540, Japan) V.1- 1967- Volume(issue)/page/year: 20,91,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: JODUA2 Journal of Osaka Dental University. (Osaka Dental Univ., 1-47, Kyobashi Higashi-ku, Osaka 540, Japan) V.1- 1967- Volume(issue)/page/year: 19,87,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: SIGAAE Shika Igaku. Odontology. (Osaka Shika Gakkai, 1-47 Kyobashi, Higashi-ku, Osaka 540, Japan) V.1- 1930- Volume(issue)/page/year: 49,837,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 200 mg/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 26(1),16A,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1400 mg/kg

SEX/DURATION :: female 11-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 22,47,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0985 No. of Facilities: 404 (estimated) No. of Industries: 10 No. of Occupations: 7 No. of Employees: 6655 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0985 No. of Facilities: 3273 (estimated) No. of Industries: 73 No. of Occupations: 46 No. of Employees: 44885 (estimated) No. of Female Employees: 3814 (estimated)

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H290-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
37/38-41

[ Safety Phrases ]:
S26-S39

[ RIDADR ]:
UN 3265

[ WGK Germany ]:
2

[ RTECS ]:
SZ8562100

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2931900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Acetyl chloride
acetic acid
Formaldehyde
Pentyl acetate
Acetamide
Ethyl 2-oxocyclohexanecarboxylate
2-Methoxy carbonyl cyclopentanone
P-cresyl acetate

DownStream

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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