Acetamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylamino)-9-oxobenzo[a]heptalen-7-yl]-

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Names

[ CAS No. ]:
2826-80-4

[ Name ]:
Acetamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylamino)-9-oxobenzo[a]heptalen-7-yl]-

[Synonym ]:
10-methylaminocolchiceine
N-methyl colchiceinamide
MB 432

Chemical & Physical Properties

[ Density]:
1.24g/cm3

[ Boiling Point ]:
724.3ºC at 760 mmHg

[ Molecular Formula ]:
C22H26N2O5

[ Molecular Weight ]:
398.45200

[ Flash Point ]:
391.9ºC

[ Exact Mass ]:
398.18400

[ PSA ]:
85.89000

[ LogP ]:
3.36860

[ Vapour Pressure ]:
7.79E-21mmHg at 25°C

[ Index of Refraction ]:
1.594

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GH0878600
CHEMICAL NAME :
Colchicine, 10-demethoxy-10-methylamino-
CAS REGISTRY NUMBER :
2826-80-4
BEILSTEIN REFERENCE NO. :
2788038
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C22-H26-N2-O5
MOLECULAR WEIGHT :
398.50
WISWESSER LINE NOTATION :
L B677 MV&T&J CO1 DO1 EO1 JMV1 NM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
759 ug/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Colchicine
  • methylamine
  • N,N-Dimethylformamide

DownStream

Related Compounds

  • 2-Ethoxy-4-fluoro-1-(3-methylbut-2-en-2-yl)benzene
  • 2-(2-{[(Tert-butoxy)carbonyl]amino}phenyl)butanedioic acid
  • 7-(2,2,2-trifluoroethyl)-4H,5H,6H,7H-thieno[2,3-c]pyridine
  • 7,7-bis(methoxymethyl)-4H,5H,6H,7H-thieno[2,3-c]pyridine
  • 4-{4H,5H,6H,7H-furo[3,2-c]pyridin-4-yl}-1,2-thiazole
  • 2-[({3-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]oxolan-2-yl}formamido)oxy]propanoic acid
  • 4-Chloro-2-methoxy-6-(nitromethyl)phenol
  • 4-({3-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]oxolan-2-yl}formamido)-2-methylbut-2-enoic acid
  • rac-1-[(1R,2S)-2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclopropanecarbonyl]-3-hydroxypiperidine-3-carboxylic acid
  • 4-(3-methoxypropyl)-4-methyl-4H,5H,6H,7H-thieno[3,2-c]pyridine
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