KRN-633

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Names

[ CAS No. ]:
286370-15-8

[ Name ]:
KRN-633

[Synonym ]:
N-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}-N'-propylurea
N-(2-chloro-4-((6,7-dimethoxy-4-quinazolinyl)oxy)phenyl)-N'-propylurea
Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propyl-
1-(2-chloro-4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-propylurea
1-{2-chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea
KRN633,KRN-633,KRN 633
S1557_Selleck
1-{2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}-3-propylurea
KRN633
VEGF Receptor Tyrosine Kinase Inhibitor III,KRN633
KRN 633
KRN-633

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
545.6±50.0 °C at 760 mmHg

[ Melting Point ]:
229 °C

[ Molecular Formula ]:
C20H21ClN4O4

[ Molecular Weight ]:
416.858

[ Flash Point ]:
283.7±30.1 °C

[ Exact Mass ]:
416.125122

[ PSA ]:
98.09000

[ LogP ]:
4.14

[ Appearance of Characters ]:
white to beige

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.629

[ Storage condition ]:
?20°C

[ Water Solubility ]:
DMSO: soluble3mg/mL, clear (warmed)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)-oxy]aniline
  • Triphosgene
  • SodiuM bicarbonate

DownStream

Related Compounds

  • EML-633
  • DKFZ-633
  • Iron, 2-[[4-[[2,4-diamino-5-[(2-hydroxy-5-sulfophenyl)azo]phenyl]azo]phenyl]amino]-5-nitrobenzenesulfonate sodium complexes
  • 1,5-Naphthalenedisulfonic acid, 2-[2-[8-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-1-hydroxy-3,6-disulfo-2-naphthalenyl]diazenyl]-, sodium salt (1:), reaction products with sodium 2,4-diamino-5-[2-[4-[[2-(sulfooxy)ethyl]sulfonyl]phenyl]diazenyl]benzenesulfonate (1:)
  • albumin blue 633
  • L-759633
  • 2-(1-Benzylpiperidin-4-yl)-4,5,6,7-tetrahydrobenzoxazole
  • 1-(2-Chloroethyl)azetidin-3-OL
  • 1-Benzyl-3-hydrazinylazetidine
  • N-(cyanomethyl)-2-(2-cyanophenoxy)propanamide
  • Methyl 3-(((4-(methoxycarbonyl)benzyl)oxy)methyl)benzoate
  • N-(2,3-dihydro-1H-inden-5-yl)-2-{[3-(2,3-dimethylphenyl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl}acetamide
  • rac 2-Isopropyl pentanoic acid ethyl ester
  • N-(2,3-dihydro-1H-inden-1-yl)-2-{[3-(2,3-dimethylphenyl)-4-oxo-3H,4H-thieno[3,2-d]pyrimidin-2-yl]sulfanyl}acetamide
  • N-[[3-(2H-Benzotriazol-2-yl)-2-hydroxy-5-methylphenyl]methyl]-2-methyl-2-propenamide
  • 1-(Tert-butyl) 2-methyl (S)-4-methyl-2,3-dihydro-1H-pyrrole-1,2-dicarboxylate
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