N-CARBOBENZYLOXY-D-PHENYLALANINE+

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Names

[ CAS No. ]:
28709-70-8

[ Name ]:
N-CARBOBENZYLOXY-D-PHENYLALANINE+

[Synonym ]:
MFCD00063151
Z-Phe-OCH2CH3
N-benzyl-L-proline ethyl ester
Cbz-phenylalanine ethyl ester
Cbz-Phe-OEt
N-benzyloxycarbonyl-L-phenylalanine ethyl ester

Chemical & Physical Properties

[ Density]:
1.162g/cm3

[ Boiling Point ]:
489ºC at 760mmHg

[ Melting Point ]:
85-88ºC

[ Molecular Formula ]:
C17H17NO4

[ Molecular Weight ]:
299.32100

[ Flash Point ]:
249.5ºC

[ Exact Mass ]:
299.11600

[ PSA ]:
75.63000

[ LogP ]:
2.99960

[ Vapour Pressure ]:
2.76E-11mmHg at 25°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AY3277300
CHEMICAL NAME :
Alanine, N-benzyloxycarbonyl-3-phenyl-, ethyl ester, L-
CAS REGISTRY NUMBER :
28709-70-8
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C19-H21-N-O4
MOLECULAR WEIGHT :
327.41
WISWESSER LINE NOTATION :
2OVY1R&MVO1R -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
501 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 20,1578,1977

Safety Information

[ Safety Phrases ]:
S22-S24/25

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethanol
  • N-Cbz-L-Phenylalanine
  • AC-PHE-OET
  • Benzyl chloroformate
  • N-carbobenzyloxy-dl-phenylalanine
  • Ethyl chloroformate
  • Diethyl pyrocarbonate
  • benzyl 4-benzyl-2,5-dioxooxazolidine-3-carboxylate
  • N-benzyloxycarbonyl-L-phenylalanyl-L-alanine
  • Z-L-Phe-O(t-Bu)

DownStream

  • (S)-Cbz-Phenylalaninol
  • (S)-(-)-2-(Benzylcarbonylamino)-3-phenylpropanal
  • zpck
  • (3s,4s)-4-amino-3-hydroxy-5-phenylpentanoic acid

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • N-Carbobenzyloxy-D-asparagine
  • (+)-N-CARBOBENZYLOXY-D-PROLINE METHYL ESTER
  • Benzyl [(3R)-2-oxo-3-oxetanyl]carbamate
  • cbz-d-alanine methyl ester
  • N-Cbz-D-threonine
  • benzyl N-(2-oxothiolan-3-yl)carbamate