Oxcarbazepine

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Names

[ CAS No. ]:
28721-07-5

[ Name ]:
Oxcarbazepine

[Synonym ]:
10,11-Dihydro-10-oxo-5h-dibenz[b,f]azepine-5-carboxamide,Oxacarbazepine
10,11-Dihydro-10-oxo-5h-dibenz[b,f]azepine-5-carboxamide Oxacarbazepine
Oxecarb
OXCARBAMAZEPINE
Trileptal
Oxcarbapezine
Ocarbazepine
Oxetol
Aurene
Oxcarbazepine
10-Oxo-10,11-dihydro-dibenzo[b,f]azepine-5-carboxylic acid amide
10,11-Dihydro-10-oxo-5H-dibenzo[b,f]azepine-5-carboxamide
10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide
10-Oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide
5H-Dibenz[b,f]azepine-5-carboxamide, 10,11-dihydro-10-oxo-
EINECS 249-188-8
OXACARBAZEPINE
MFCD00865307

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
457.2±55.0 °C at 760 mmHg

[ Melting Point ]:
215-216°C

[ Molecular Formula ]:
C15H12N2O2

[ Molecular Weight ]:
252.268

[ Flash Point ]:
230.3±31.5 °C

[ Exact Mass ]:
252.089874

[ PSA ]:
63.40000

[ LogP ]:
1.44

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.662

[ Storage condition ]:
Store at RT

[ Water Solubility ]:
DMSO: ~9 mg/mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HN8445000
CHEMICAL NAME :
5H-Dibenz(b,f)azepine-5-carboxamide, 10,11-dihydro-10-oxo-
CAS REGISTRY NUMBER :
28721-07-5
LAST UPDATED :
199806
DATA ITEMS CITED :
1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
14300 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 279,1237,1996

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn,F

[ Risk Phrases ]:
22-36-20/21/22-11

[ Safety Phrases ]:
16-36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
HN8445000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Licarbazepine
  • 10-Methoxy Iminostilbene
  • Sodium cyanate
  • 10-Methoxycarbamazepine
  • 10,11-Dihydrocarbamazepine
  • Benzaldehyde
  • Triphosgene
  • Chlorosulfonylisocyanate
  • 5,11-Dihydro-10H-dibenzo[b,f]azepin-10-one
  • ch3cho

DownStream

  • Dibenzazepine-10,11-dione
  • r-10-monohydroxy-dihydro-carbamazepin
  • Eslicarbazepine
  • (11-carbamoyl-5-oxo-6H-benzo[b][1]benzazepin-6-yl) acetate
  • 5,11-Dihydro-10H-dibenzo[b,f]azepin-10-one
  • Licarbazepine

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

  • Oxcarbazepine-d4
  • Oxcarbazepine-D4
  • 11-Keto Oxcarbazepine
  • N-Formyl Oxcarbazepine
  • 10-Bromo-Oxcarbazepine
  • Oxcarbazepine N-Sulfate
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-Amino-2'-chloroazobenzene
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide