Hexadimethrine bromide
Suppliers
Names
[ CAS No. ]:
28728-55-4
[ Name ]:
Hexadimethrine bromide
[Synonym ]:
Hexadimethrine bromide,Polybrene
HEXADIMETHRINE BROMIDE
1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide,Polybrene
MFCD00133397
Chemical & Physical Properties
[ Boiling Point ]:
209.5ºC at 760 mmHg
[ Molecular Formula ]:
C15H36Br2N2
[ Molecular Weight ]:
404.27
[ Flash Point ]:
73.9ºC
[ Vapour Pressure ]:
0.202mmHg at 25°C
[ Storage condition ]:
2-8℃
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TQ2655000
- CHEMICAL NAME :
- Poly((dimethyliminio)hexamethylene(dimethylimino)trim ethylene dibromide)
- CAS REGISTRY NUMBER :
- 28728-55-4
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 4
- WISWESSER LINE NOTATION :
- /E3E &1N1&5N1&1/
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4013507
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4013507
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 37,267,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 28 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4013507
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R20/21/22
[ RIDADR ]:
UN 2811
[ RTECS ]:
TQ2655000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
Articles
Cell Death Dis. 6 , e1841, (2015)
Dual specificity protein phosphatase 26 (DUSP26) is overexpressed in high-risk neuroblastoma (NB) and contributes to chemoresistance by inhibiting p53 function. In vitro, DUSP26 has also been shown to...
Virology 476 , 377-85, (2015)
Ectopic expression of Simian Virus 40 (SV40) large T antigen (LT) in mouse embryonic fibroblasts (MEFs) increased levels of mRNAs encoding interferon stimulated genes (ISGs). The mechanism by which T ...
Neurosci. Lett. 600 , 164-70, (2015)
Polybrene is widely used to enhance viral transduction; however, little is known about the utility thereof, in enhancing lentiviral transduction of cochlear cells. In the present study, we examined th...