Apratastat

Suppliers

Names

[ Name ]:
Apratastat

[Synonym ]:
(3S)-N-Hydroxy-4-({4-[(4-hydroxy-2-butyn-1-yl)oxy]phenyl}sulfonyl)-2,2-dimethyl-3-thiomorpholinecarboxamide
TMI 005
(3S)-N-hydroxy-4-({4-[(4-hydroxybut-2-yn-1-yl)oxy]phenyl}sulfonyl)-2,2-dimethylthiomorpholine-3-carboxamide
MFCD13152357
3-Thiomorpholinecarboxamide, N-hydroxy-4-[[4-[(4-hydroxy-2-butyn-1-yl)oxy]phenyl]sulfonyl]-2,2-dimethyl-, (3S)-
Apratastat

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₁₇H₂₂N₂O₆S₂

[ Molecular Weight ]:
414.496

[ Exact Mass ]:
414.091919

[ LogP ]:
1.42

[ Index of Refraction ]:
1.607

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Articles

ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice. Ford BM et al

Am. J. Physiol. Renal Physiol. 305(3) , F323-32, (2013)

Pharmacokinetic-pharmacodynamic modeling of apratastat: a population-based approach. Shu C et al

J. Clin. Pharmacol. 51(4) , 472-81, (2011)