1H-Indene-1,3(2H)-dione,2-[(dimethylamino)methylene]-

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Names

[ CAS No. ]:
28752-91-2

[ Name ]:
1H-Indene-1,3(2H)-dione,2-[(dimethylamino)methylene]-

[Synonym ]:
2-dimethylaminomethylene-1,3-indandione
2-dimethylaminomethyleneindane-1,3-dione
2-Dimethylaminomethyliden-1,3-indandion
Dimethylaminomethylene-2 indanedione-1,3 [French]
COR 3761
2-Dimethylaminomethylen-1,3-indandion
2-[(dimethylamino)methylene]-1H-indene-1,3(2H)-dione
1H-indene-1,3(2H)-dione,2-[(dimethylamino)methylene]
1,3-Indandione,2-((dimethylamino)methylene)
2-dimethylaminomethylene-1,3-indendione

Chemical & Physical Properties

[ Density]:
1.319g/cm3

[ Boiling Point ]:
324.7ºC at 760 mmHg

[ Molecular Formula ]:
C12H11NO2

[ Molecular Weight ]:
201.22100

[ Flash Point ]:
142.6ºC

[ Exact Mass ]:
201.07900

[ PSA ]:
37.38000

[ LogP ]:
1.51110

[ Vapour Pressure ]:
0.000242mmHg at 25°C

[ Index of Refraction ]:
1.684

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NK8390355
CHEMICAL NAME :
1H-Indene-1,3(2H)-dione, 2-((dimethylamino)methylene)-
CAS REGISTRY NUMBER :
28752-91-2
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H11-N-O2
MOLECULAR WEIGHT :
201.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
520 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0172128
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
440 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 10,320,1976

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,3-INDANDIONE
  • N,N-Dimethylformamide dimethyl acetal
  • (2-Chlor-1,3-dioxo-indan-2-yl)-methansulfonylchlorid
  • Dimethylamine
  • Kalium-(2-chlor-1,3-dioxo-indan-2-yl)-methansulfonat

DownStream

Related Compounds

  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4-{[3-(Methylsulfanyl)phenyl]methyl}piperidine
  • Piperidine, 2-(2-oxazolyl)-
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine