Pirenzepine

Suppliers

Names

[ Name ]:
Pirenzepine

[Synonym ]:
6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-
Piclamilast
11-[(4-Methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 5,11-dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-
6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 5,11-dihydro-11-[2-(4-methyl-1-piperazinyl)acetyl]-
Cpodpmb
11-[(4-Methyl-1-piperazinyl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Pirenzepine
Gastrozepin

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
541.7±50.0 °C at 760 mmHg

[ Melting Point ]:
226 - 230ºC

[ Molecular Formula ]:
C₁₉H₂₃Cl₂N₅O₂

[ Molecular Weight ]:
351.402

[ Flash Point ]:
281.4±30.1 °C

[ Exact Mass ]:
351.169525

[ PSA ]:
74.23000

[ LogP ]:
-0.08

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.615

[ Storage condition ]:
Store at RT

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU7882950

CHEMICAL NAME :: 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-

CAS REGISTRY NUMBER :: 28797-61-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H21-N5-O2

MOLECULAR WEIGHT :: 351.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 26,245,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3046 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 26,245,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 427 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 26,245,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 156 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 26,245,1991

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

11-[2-(4-methylpiperazin-1-yl)acetyl]-1-oxido-5H-pyrido[2,3-b][1,4]benzodiazepin-1-ium-6-one
2-Amino-N-(2-chloro-3-pyridinyl)benzamide
5,6-Dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine
3-(2'-chlorobenzoyl)amino-2-chloropyridine
methylpiperazine
1-oxo-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
3-(2'-bromobenzoyl)amino-2-chloropyridine
2-amino-N-(2-chloro-1-oxidopyridin-1-ium-3-yl)benzamide
2-chloro-N-(2-chloro-1-oxidopyridin-1-ium-3-yl)benzamide
2-bromo-N-(2-chloro-1-oxidopyridin-1-ium-3-yl)benzamide