Imidazole

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Names

[ CAS No. ]:
288-32-4

[ Name ]:
Imidazole

[Synonym ]:
IMD
1,3-Diaza-2,4-cyclopentadiene,Glyoxaline
GLYOXALIN
LMIDAZOLE
glioksal
1,3-diaza-2,4-cyclopentadiene
Imidazol
Miazole
1,3-imidazole
Imidazoie
Imidazole
MFCD00005183
1-imidazole
EINECS 206-019-2
Imidazole buffer
IMINAZOLE
1,3-diazole
Imutex
Clotrimazole Impurity 4

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
257.0±9.0 °C at 760 mmHg

[ Melting Point ]:
88-91 °C(lit.)

[ Molecular Formula ]:
C₃H₄N₂

[ Molecular Weight ]:
68.077

[ Flash Point ]:
145.0±0.0 °C

[ Exact Mass ]:
68.037445

[ PSA ]:
28.68000

[ LogP ]:
-0.16

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.528

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with acids, strong oxidizing agents. Protect from moisture.

[ Water Solubility ]:
633 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI3325000

CHEMICAL NAME :: Imidazole

CAS REGISTRY NUMBER :: 288-32-4

BEILSTEIN REFERENCE NO. :: 0103853

LAST UPDATED :: 199710

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C3-H4-N2

MOLECULAR WEIGHT :: 68.09

WISWESSER LINE NOTATION :: T5M CNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 626 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 880 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 817 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 475 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Behavioral - rigidity (including catalepsy) Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 760 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 150 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - impotence

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 1 mmol/L

REFERENCE :: JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 65,400,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1601 No. of Facilities: 158 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 1401 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1601 No. of Facilities: 313 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 3009 (estimated) No. of Female Employees: 2411 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H314-H360D

[ Precautionary Statements ]:
P201-P260-P280-P303 + P361 + P353-P305 + P351 + P338-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R22;R34;R63

[ Safety Phrases ]:
S26-S36/37/39-S45-S22-S36

[ RIDADR ]:
UN 2923 8/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
NI3325000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

N-tert-Butoxycarbonylimidazole
1-(P-Toluenesulfonyl)imidazole
1H-Imidazole hydrochloride
1-Allylimidazole
2-imidazol-1-yl-1-phenylethanone
1-benzylimidazole
1-Trityl-1H-imidazole
1-benzhydrylimidazole
Salicylaldehyde
2-triphenyl(α-carboxymethylene)phosphorane imidazolide

DownStream

imidazol-1-yl-(4-methoxyphenyl)methanone
1H-Imidazole-2-carboxaldehyde,1-(phenylmethyl)-
tert-butyl-cyclohex-3-en-1-yloxy-dimethylsilane
1,1-Di(1H-imidazol-1-yl)methanimine
Acetylimidazole diethyl acetal
METHYL 6-(1H-IMIDAZOL-1-YL)NICOTINATE
2-(2,4-dichlorophenyl)-2-hydroxy-1-imidazol-1-yl-4-methylpentan-3-one
2-(2,4-dichlorophenyl)-2-hydroxy-3-imidazol-1-yl-1-phenylpropan-1-one
4-(t-butyldimethylsiloxy)butyne
tert-butyl-dimethyl-(4-trimethylsilylbut-3-ynoxy)silane

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Imidazole
Imidazole-d4
Imidazole-d3
1H-Imidazole
1H-Imidazole
4H-imidazole
(2R)-1-(3,5-difluorophenyl)propan-2-amine
2-Fluoro-1-(3-methylphenyl)ethan-1-ol
Ethyl 1-ethynylcyclopropane-1-carboxylate
5-(2-Fluoropropan-2-yl)pyridin-3-amine
2-(1-propyl-1H-1,2,3-triazol-4-yl)acetic acid
Methyl 1-(6-ethynylnaphthalen-2-yl)cyclopropane-1-carboxylate
tert-butyl N-[4-(4-aminophenyl)-1,2,5-oxadiazol-3-yl]carbamate
(2-((4-Methoxybenzyl)amino)thieno[2,3-D]thiazol-5-YL)methanol
2-(2-((4-Methoxybenzyl)amino)thieno[2,3-D]thiazol-5-YL)acetonitrile
Ethyl 1-(2-aminothieno[2,3-D]thiazol-5-YL)cyclopropane-1-carboxylate

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