SB408124

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
430.3±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₈F₂N₄O

[ Molecular Weight ]:
356.369

[ Flash Point ]:
214.0±28.7 °C

[ Exact Mass ]:
356.144867

[ PSA ]:
57.26000

[ LogP ]:
4.53

[ Appearance of Characters ]:
solid | olive-green

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.697

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: ~24 mg/mL

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

A major role for perifornical orexin neurons in the control of glucose metabolism in rats.

Diabetes 58(9) , 1998-2005, (2009)

The hypothalamic neuropeptide orexin influences (feeding) behavior as well as energy metabolism. Administration of exogenous orexin-A into the brain has been shown to increase both food intake and blo...

Hypocretin/orexin type 1 receptor in brain: role in cardiovascular control and the neuroendocrine response to immobilization stress.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 292(1) , R382-7, (2007)

Hypocretin/orexin acts pharmacologically in the hypothalamus to stimulate stress hormone secretion at least in part by an action in the hypothalamic paraventricular nucleus, where the peptide's recept...

Modulation of respiratory activity by hypocretin-1 (orexin A) in situ and in vitro.

Adv. Exp. Med. Biol. 669 , 109-13, (2010)

Release of hypocretins (orexins) by neurons in the lateral hypothalamus is an important contributor to arousal state, thermoregulation, feeding behavior, and has recently been proposed to play a role ...

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