4-Fluoro-5-hydroxy-2-methylindole

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Names

[ CAS No. ]:
288385-88-6

[ Name ]:
4-Fluoro-5-hydroxy-2-methylindole

[Synonym ]:
1H-Indol-5-ol, 4-fluoro-2-methyl-
4-Fluoro-5-hydroxy-2-methylindole
4-Fluoro-2-methyl-1H-indol-5-ol
HIN1687
4-fluoro-5-hydroxy-2-methyl-1H-indole
T56 BMJ C1 FF GQ
2-methyl-4-fluoro-5-hydroxyindole
2-methyl-4-fluoro-1H-indol-5-ol
MFCD07368140

Chemical & Physical Properties

[ Density]:
1.367

[ Boiling Point ]:
327.3±37.0 °C at 760 mmHg

[ Molecular Formula ]:
C9H8FNO

[ Molecular Weight ]:
165.164

[ Flash Point ]:
151.8±26.5 °C

[ Exact Mass ]:
165.058990

[ PSA ]:
36.02000

[ LogP ]:
1.66

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.672

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-Acetylmethyl-1-benzyloxy-2-fluoro-4-nitrobenzene
  • 4-Fluoro-5-methoxy-2-methyl-1H-indole
  • 1-(2-Fluoro-3-hydroxy-6-nitrophenyl)propan-2-one

DownStream

  • Brivanib (BMS-540215)
  • 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-ol
  • 7-(Benzyloxy)-4-(4-Fluoro-2-Methyl-1h-Indol-5-Yloxy)-6-Methoxyquinazoline

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 4-fluoro-5-hydroxy-2-nitrobenzoic acid
  • 4-Fluoro-5-hydroxy-2-pyridinecarbaldehyde
  • methyl 4-fluoro-5-hydroxy-2-nitrobenzoate
  • [1-(4-chlorobenzoyl)-4-fluoro-5-hydroxy-2-methyl-1H-indol-3-yl]acetic acid
  • 4-Fluoro-5-hydroxy-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one
  • 4-Fluoro-5-hydroxy-1-indanone