2-Butenamide,N-(aminocarbonyl)-2-ethyl-, (E)- (9CI)

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Names

[ Name ]:
2-Butenamide,N-(aminocarbonyl)-2-ethyl-, (E)- (9CI)

[Synonym ]:
(2-Ethyl-trans-crotonyl)harnstoff
(2-ethyl-trans-crotonoyl)-urea
MA-117
(2-Ethylcrotonoyl)urea
(E)-N-carbamoyl-2-ethyl-but-2-enamide
(2-Aethyl-trans-crotonoyl)-harnstoff
trans-2-Ethyl-crotonylharnstoff

Chemical & Physical Properties

[ Density]:
1.082g/cm3

[ Molecular Formula ]:
C₇H₁₂N₂O₂

[ Molecular Weight ]:
156.18200

[ Exact Mass ]:
156.09000

[ PSA ]:
72.19000

[ LogP ]:
1.62880

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YT2700000

CHEMICAL NAME :: Urea, (2-ethylcrotonoyl)-, trans-

CAS REGISTRY NUMBER :: 2884-67-5

LAST UPDATED :: 199506

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C7-H12-N2-O2

MOLECULAR WEIGHT :: 156.21

WISWESSER LINE NOTATION :: ZVMVY2&U2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - somnolence (general depressed activity)

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 12,357,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 575 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 114,418,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 14,845,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 990 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 5,293,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 114,418,1958

Related Compounds

tert-butyl N-[(1S)-1-(3-fluoro-4-methoxyphenyl)-3-oxopropyl]carbamate
tert-butyl N-[(1S)-1-(2,5-dichlorophenyl)-3-oxopropyl]carbamate
tert-butyl N-[(1S)-1-(4-fluoro-3-methylphenyl)-3-oxopropyl]carbamate
3-(2-Fluoro-2-methylpropyl)-1,1-dioxo-1lambda6-thietane-3-carbaldehyde
1-(3-Hydroxy-2,2-dimethylpropyl)cyclobutane-1-carbaldehyde
6-(3-bromo-1H-pyrazol-1-yl)-5-chloropyridine-3-carbaldehyde
2-(1-Methoxyethyl)oxane-2-carbaldehyde
tert-butyl N-[2-(1-ethyl-1H-1,2,4-triazol-5-yl)-1-oxopropan-2-yl]-N-methylcarbamate
4-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylbutanamido]but-2-ynoic acid
2-{4-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)but-2-ynoyl]piperazin-1-yl}acetic acid

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