Carbidopa
Suppliers
Names
[ CAS No. ]:
28860-95-9
[ Name ]:
Carbidopa
[Synonym ]:
Benzenepropanoic acid, α-hydrazinyl-3,4-dihydroxy-α-methyl-, (αS)-, hydrate (1:1)
Carbidopa
(S)-Carbidopa
1-a-(3,4-Dihydroxybenzyl)-a-hydrazinopropionic Acid
MFCD00069231
L-a-Methyldopahydrazine
(aS)-a-Hydrazino-3,4-dihydroxy-a-methylbenzenepropanoic Acid
a-Methyldopahydrazine
Lodosin
EINECS 249-271-9
carbidopa [INN_en]
(S)-(-)-Carbidopa
HMD
(2S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid hydrate (1:1)
(2S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid
S-(−)-Carbidopa
Benzenepropanoic acid, α-hydrazinyl-3,4-dihydroxy-α-methyl-, (αS)-
benzenepropanoic acid, α-hydrazino-3,4-dihydroxy-α-methyl-, (αS)-
(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate (1:1)
benzenepropanoic acid, a-hydrazinyl-3,4-dihydroxy-a-methyl-, (aS)-
Benzenepropanoic acid, α-hydrazino-3,4-dihydroxy-α-methyl-, (S)-
S-(-)-Carbidopa
(-)-L-a-Hydrazino-3,4-dihydroxy-a-methylhydrocinnamic Acid
(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
Hydrazino-a-methyldopa
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
528.7±50.0 °C at 760 mmHg
[ Melting Point ]:
206 - 208ºC
[ Molecular Formula ]:
C10H14N2O4
[ Molecular Weight ]:
226.23
[ Flash Point ]:
273.5±30.1 °C
[ PSA ]:
115.81000
[ LogP ]:
-0.19
[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C
[ Index of Refraction ]:
1.641
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MW5298000
- CHEMICAL NAME :
- Hydrocinnamic acid, alpha-hydrazino-3,4-dihydroxy-alpha-methyl-, L-
- CAS REGISTRY NUMBER :
- 28860-95-9
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C10-H14-N2-O4
- MOLECULAR WEIGHT :
- 226.26
- WISWESSER LINE NOTATION :
- ZMX1&VQ1R CQ DQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2804 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 468 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 23400 mg/kg/90D-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2100 mg/kg
- SEX/DURATION :
- female 1-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2880 mg/kg
- SEX/DURATION :
- female 90 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - uterus, cervix, vagina
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 1 mg/plate
- REFERENCE :
- RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 49,415,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4821 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 303 (estimated) No. of Female Employees: 166 (estimated)
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
MW5298000
[ HS Code ]:
2932999099
Customs
[ HS Code ]: 2932999099
[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
BMJ Case Rep. 2012 , doi:10.1136/bcr-2012-006868, (2012)
Brain Res. 1497 , 1-14, (2013)
Levodopa (L-DOPA) is widely used for symptomatic management in Parkinson's disease. We recently showed that (-)-epigallocatechin-3-gallate, a tea polyphenol, not only inhibits L-DOPA methylation, but ...
Ir. Med. J. 106(1) , 24-5, (2013)
Impulse control disorders (ICDs) are a known side effect of dopamine replacement therapy in patients with Parkinson's disease (PD). They can have devastating consequences for patients and their famili...