tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate

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Names

[ CAS No. ]:
289042-12-2

[ Name ]:
tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate

[Synonym ]:
Rosuvastatin intermediate R-2
Rosuvastatin calciuM interMediate R-2
6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, 1,1-dimethylethyl ester, (3R,5S,6E)-
MFCD08458343
1,3-Dioxane-4-acetic acid, 6-[(E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-, 1,1-dimethylethyl ester
Rosuvastatin Acetonide t-Butyl Ester
Rosuvastatin tert-Butyl Ester
tert-Butyl {6-[(E)-2-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetate
2-Methyl-2-propanyl {6-[(E)-2-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetate
tert-Butyl rosuvastatin
tert-butyl (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
R-1 interMediate
2-Methyl-2-propanyl (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}-3,5-dihydroxy-6-heptenoate
tert-Butyl (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoate

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
704.2±70.0 °C at 760 mmHg

[ Melting Point ]:
153-155°C

[ Molecular Formula ]:
C26H36FN3O6S

[ Molecular Weight ]:
537.644

[ Flash Point ]:
379.7±35.7 °C

[ Exact Mass ]:
537.230896

[ PSA ]:
116.30000

[ LogP ]:
2.24

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.564

[ Storage condition ]:
Refrigerator

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methanesulfonamide,N-[5-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl
  • tert-Butyl (4R-cis)-6-formaldehydel-2,2-dimethyl-1,3-dioxane-4-acetate
  • tert-butyl 2-[(4R,6S)-6-[(benzo[d]thiazol-2-ylsulfonyl)methyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate
  • N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide
  • N-(5-bromo-4-(4-fluorophenyl)-6-isopropylpyriinidin-2-yl)-N-methylmethanesulfonamide
  • tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4'-fluorophenyl)-6-isopropyl-2-(methylamino)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate
  • Methanesulfonyl chloride
  • N-[4-(4-fIuoro-phenyl)-6-isopropyI-5-(pyridine-2-sulfonyImethyl)-pyrimidin-2-yl]-N-methyI-methanesuIfonamide

DownStream

  • tert-Butyl rosuvastatin
  • Rosuvastatin

Related Compounds

  • N-[3-(1-aminocyclohexyl)propyl]propane-1-sulfonamide
  • 4-Bromo-3-{[cyclopropyl(methyl)amino]methyl}benzoic acid
  • 5-{[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)oxan-4-yl]formamido}hexanoic acid
  • 2-{8,8-Dimethoxyspiro[4.5]decan-7-yl}ethan-1-amine
  • Ethyl 4-{2-amino-7-azabicyclo[2.2.1]heptan-7-yl}-4-oxobutanoate
  • 1-(Pent-4-en-2-yl)cyclopropane-1-sulfonyl chloride
  • 3-amino-4-(1H-imidazol-4-yl)benzoic acid
  • 2-Bromo-6-(3-methylpiperidin-1-yl)pyridine-4-carboxylic acid
  • 1-(5-Bromopentyl)cyclopropane-1-carboxylic acid
  • 1-{7-Azabicyclo[2.2.1]heptan-2-yl}-3-propylurea