Oridonin

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Names

[ CAS No. ]:
28957-04-2

[ Name ]:
Oridonin

[Synonym ]:
ORIDONIN
Rubescensin
ISODONAL
(1α,5β,6β,7β,8α,9β,10α,13α,14R)-1,6,7,14-Tetrahydroxy-7,20-epoxykaur-16-en-15-one
RUBESCENSIN A
7a,20-Epoxy-1a,6b,7,14-tetrahydroxy-Kaur-16-en-15-one Isodonol
Isodonol
megathyrin A
Rabdosia rubescens

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
599.8±50.0 °C at 760 mmHg

[ Melting Point ]:
248-250ºC

[ Molecular Formula ]:
C20H28O6

[ Molecular Weight ]:
364.433

[ Flash Point ]:
215.0±23.6 °C

[ Exact Mass ]:
364.188599

[ PSA ]:
107.22000

[ LogP ]:
1.44

[ Vapour Pressure ]:
0.0±3.9 mmHg at 25°C

[ Index of Refraction ]:
1.635

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: >20mg/mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NZ8177000
CHEMICAL NAME :
Kaur-16-en-15-one, 7-alpha,20-epoxy-1-alpha,6-beta,7,14-tetrahydroxy-, (14R)-
CAS REGISTRY NUMBER :
28957-04-2
LAST UPDATED :
198909
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H28-O6
MOLECULAR WEIGHT :
364.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Ascites tumor
DOSE/DURATION :
40 mg/L
REFERENCE :
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 9,465,1988

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351

[ Precautionary Statements ]:
P281

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
40

[ Safety Phrases ]:
36/37-24/25

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
NZ8177000

[ HS Code ]:
2942000000

Precursor & DownStream

Precursor

DownStream

  • 14-O-butanoyl oridonin
  • 14-O-hexanoyl oridonin
  • Kaur-16-en-15-one,7,20-epoxy-1,6,7-trihydroxy-14-[(1-oxodecyl)oxy]-, (1a,6b,7a,14R)- (9CI)
  • Kaur-16-en-15-one,7,20-epoxy-1,6,7-trihydroxy-14-[(1-oxododecyl)oxy]-, (1a,6b,7a,14R)- (9CI)
  • 14-O-tetradecanoyl oridonin
  • 14-O-hexadecanoyl oridonin
  • kt-1 (from kyoto university)

Customs

[ HS Code ]: 2942000000

Articles

[Anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines].

Sichuan Da Xue Xue Bao. Yi Xue Ban 43(3) , 362-6, (2012)

To study the anti-tumor effect of tanshinon II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines SUP-B15, K562, CEM, HL-60 and NB4.To study the anti-tumor effect of tansh...

Induction of human CYP3A4 by huperzine A, ligustrazine and oridonin through pregnane X receptor-mediated pathways.

Pharmazie 69(7) , 532-6, (2014)

The pregnane X receptor (PXR) is a key regulator of CYP3A4, which is involved in catalyzing the metabolic conversion of a number of endogenous substrates. In this study, we screened 22 compounds isola...

The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells.

J. Gastroenterol. 48(2) , 182-92, (2013)

Fatty acid synthase (FAS) inhibitors could be a therapeutic target in cancer treatment. However, only a few FAS inhibitors showing clinical potential have been reported. Oridonin is a diterpenoid isol...


More Articles

Related Compounds

  • 1-acetyloridonin
  • 14-O-hexanoyl oridonin
  • 14-O-decanoyl oridonin
  • 14-O-butanoyl oridonin
  • oridonin 14-dodecanoate
  • 14-O-hexadecanoyl oridonin
  • 2-(3-Chloro-4-ethoxyphenyl)-4-[(4-fluorobenzyl)thio]pyrazolo[1,5-a]pyrazine
  • 2-(6-(3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl)-5-methyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)-N-(2-fluorophenyl)acetamide
  • 2-(6-(3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl)-5-methyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)-N-(m-tolyl)acetamide
  • 7-chloro-4-((3-(4-ethoxyphenyl)-1,2,4-oxadiazol-5-yl)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
  • 6-chloro-4-((3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
  • 6-methyl-4-((3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
  • 4-((3-(4-ethoxyphenyl)-1,2,4-oxadiazol-5-yl)methyl)-6-(ethylsulfonyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
  • N-(3-cyanophenyl)-2-(4-oxo-7-phenylthieno[3,2-d]pyrimidin-3(4H)-yl)acetamide
  • tert-butyl 2-(7-(2,5-dimethylphenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)acetate
  • 7-(4-methoxyphenyl)-3-(2-phenoxyethyl)thieno[3,2-d]pyrimidin-4(3H)-one