2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoic acid

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Names

[ CAS No. ]:
289686-70-0

[ Name ]:
2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoic acid

[Synonym ]:
2-[3,5-Bis(trifluoromethyl)phenyl]-2-methylpropanoic acid
Benzeneacetic acid, α,α-dimethyl-3,5-bis(trifluoromethyl)-
2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
232.5±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C12H10F6O2

[ Molecular Weight ]:
300.197

[ Flash Point ]:
94.4±25.9 °C

[ Exact Mass ]:
300.058502

[ PSA ]:
37.30000

[ LogP ]:
3.63

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.429

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • methyl α,α-dimethyl-3,5-bis(trifluoromethyl)benzeneacetate
  • carbon monoxide
  • 2-[3,5-bis-(Trifluoromethyl)phenyl]propan-2-ol
  • 3,5-Bis(trifluoromethyl)bromobenzene

DownStream

  • Netupitant
  • Befetupitant

Related Compounds

  • 2-Amino-3-(3-bromo-4-methylphenyl)-3-methylbutanoic acid
  • 2-(3-Amino-2,2,5,5-tetramethyloxolan-3-yl)-2-hydroxyacetic acid
  • 4-Amino-4-(4-hydroxy-3-nitrophenyl)butanoic acid
  • 3-(1-Hydroxy-3,3-dimethylcyclopentyl)piperidine-3-carboxylic acid
  • 3-amino-3-(1-tert-butyl-1H-pyrazol-4-yl)propanoic acid
  • 2-Amino-3-(5-bromo-2-methylphenyl)-3-hydroxypropanoic acid
  • 2-Amino-2-[1-(3-hydroxy-4-methoxyphenyl)cyclopropyl]acetic acid
  • 3-Amino-1-(2-chloro-6-hydroxyphenyl)cyclobutane-1-carboxylic acid
  • 4-Amino-4-(4-cyclopropyl-1,3-thiazol-5-yl)butanoic acid
  • 4-(3-Fluoro-2-methylphenyl)pyrrolidine-3-carboxylic acid
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