terofenamate

Suppliers

Names

[ CAS No. ]:
29098-15-5

[ Name ]:
terofenamate

[Synonym ]:
Terofenamato [INN-Spanish]
Etofen
Etoclofene
EINECS 249-434-4
Terofenamate
N-(2,6-Dichloro-m-tolyl)anthranilic acid ethoxymethyl ester
M-(2,6-Dichloro-m-tolyl)anthranilic acid ethoxymethyl ester
Ethoxymethyl N-(2,6-dichloro-m-tolyl)anthranilate
Terofenamatum [INN-Latin]

Chemical & Physical Properties

[ Density]:
1.297g/cm3

[ Boiling Point ]:
439ºC at 760 mmHg

[ Molecular Formula ]:
C17H17Cl2NO3

[ Molecular Weight ]:
354.22800

[ Flash Point ]:
219.3ºC

[ Exact Mass ]:
353.05900

[ PSA ]:
47.56000

[ LogP ]:
5.26920

[ Vapour Pressure ]:
6.6E-08mmHg at 25°C

[ Index of Refraction ]:
1.597

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CB2975100
CHEMICAL NAME :
Anthranilic acid, N-(2,6-dichloro-m-tolyl)-, ethoxymethyl ester
CAS REGISTRY NUMBER :
29098-15-5
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C17-H17-Cl2-N-O3
MOLECULAR WEIGHT :
354.25
WISWESSER LINE NOTATION :
GR CG D1 BMR BVO1O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
307 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cough
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 115,41,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
274 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cough
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 115,41,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
918 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 115,41,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 115,41,1976 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6240 mg/kg/26W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in leukocyte (WBC) count Related to Chronic Data - death
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 115,41,1976

Safety Information

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • meclofenamic acid
  • Ethoxychloromethane

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 6,10-Dioxaspiro[4.5]dec-8-ylmethanol
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 3-(3-Bromo-2-hydroxyphenyl)propanoic acid