L-685,458

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Names

[ CAS No. ]:
292632-98-5

[ Name ]:
L-685,458

[Synonym ]:
(5S)-(t-Butoxycarbonylamino)-6-phenyl-(4R)hydroxy-(2R)benzylhexanoyl)-L-leu-L-phe-amide
L-685458

Chemical & Physical Properties

[ Molecular Formula ]:
C39H52N4O6

[ Molecular Weight ]:
672.85300

[ Exact Mass ]:
672.38900

[ PSA ]:
159.85000

[ LogP ]:
6.34900

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

RAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environment.

J. Neurosci. 34(26) , 8749-60, (2014)

Ischemia is known to increase the deleterious effect of β-amyloid (Aβ), contributing to early cognitive impairment in Alzheimer's disease. Here, we investigated whether transient ischemia may function...

Suppression of Notch signaling in the neonatal mouse ovary decreases primordial follicle formation.

Endocrinology 150 , 1014-24, (2009)

Notch signaling directs cell fate during embryogenesis by influencing cell proliferation, differentiation, and apoptosis. Notch genes are expressed in the adult mouse ovary, and roles for Notch in reg...

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity.

Biochemistry 39 , 8698, (2000)

Progressive cerebral amyloid beta-protein (A beta) deposition is believed to play a central role in the pathogenesis of Alzheimer's disease (AD). Elevated levels of A beta(42) peptide formation have b...


More Articles

Related Compounds

  • L685818
  • L-arginine mono[(R)-4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-alpha-methylbenzeneacetate]
  • L-Mannitol, 1-deoxy-3,4-di-O-methyl-, triacetate
  • L-Malic acid dipotassium
  • L-Valine, N-(3-methoxy-1,3-dioxopropyl)-, methyl ester
  • L-Cysteine,S-(aminocarbonyl)-