Ciclopirox

Suppliers

Names

[ Name ]:
Ciclopirox

[Synonym ]:
Ciclopirox Olamine
6-cyclohexyl-1-hydroxy-4-méthylpyridin-2(1H)-one
Terit
6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone
MFCD00599441
Ciclopirox
6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one
Ciclopirox (USP)
Mycoster
cyclopirox
EINECS 249-577-2
6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-on
Stieprox
Loprox
Ciclopiroxum
1-Hydroxy-4-methyl-6-cyclohexyl-2-pyridone
Penlac
(6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone)
6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone
2(1H)-Pyridinone, 6-cyclohexyl-1-hydroxy-4-methyl-
6-cyclohexyl-1-hydroxy-4-methyl-1,2-dihydropyridin-2-one
Batrafen
6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
350.0±25.0 °C at 760 mmHg

[ Melting Point ]:
1440C

[ Molecular Formula ]:
C₁₂H₁₇NO₂

[ Molecular Weight ]:
207.269

[ Flash Point ]:
165.5±23.2 °C

[ Exact Mass ]:
207.125931

[ PSA ]:
42.23000

[ LogP ]:
2.59

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.582

[ Storage condition ]:
-20°C Freezer

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Hazard Codes ]:
C,O

[ Risk Phrases ]:
R8:Contact with combustible material may cause fire. R35:Causes severe burns. R34:Causes burns. R20:Harmful by inhalation.

[ Safety Phrases ]:
S23-S26-S36-S45

[ RIDADR ]:
UN 3264 8/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
QU5900000

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2933790090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Effect of Wnt inhibitors in pancreatic cancer.

Anticancer Res. 34(10) , 5375-80, (2014)

Activated Wnt signaling in cancer cells leads to cell proliferation. It has been shown that the Wnt pathway is activated in pancreatic adenocarcinoma cells. Therefore, we tested the effect of Wnt inhi...

The low keratin affinity of efinaconazole contributes to its nail penetration and fungicidal activity in topical onychomycosis treatment.

Antimicrob. Agents Chemother. 58(7) , 3837-42, (2014)

Onychomycosis is a common fungal nail disease that is difficult to treat topically due to the deep location of the infection under the densely keratinized nail plate. Keratin affinity of topical drugs...

Thermogelling hydrogels of cyclodextrin/poloxamer polypseudorotaxanes as aqueous-based nail lacquers: application to the delivery of triamcinolone acetonide and ciclopirox olamine.

Eur. J. Pharm. Biopharm. 83(3) , 370-7, (2013)

This work investigated the use of in situ gelling hydrogels based on polypseudorotaxanes of Pluronic F-127 and partially methylated β-cyclodextrin as aqueous nail lacquers. N-acetylcysteine and urea w...