Mepazine hydrochloride

Suppliers

Names

[ CAS No. ]:
2975-36-2

[ Name ]:
Mepazine hydrochloride

[Synonym ]:
mepazine hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
444.4ºC at 760 mmHg

[ Molecular Formula ]:
C19H23ClN2S

[ Molecular Weight ]:
346.91700

[ Flash Point ]:
222.6ºC

[ Exact Mass ]:
346.12700

[ PSA ]:
31.78000

[ LogP ]:
5.43600

[ Vapour Pressure ]:
4.29E-08mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SP2800000
CHEMICAL NAME :
Phenothiazine, 10-((1-methyl-3-piperidyl)methyl)-, monohydrochloride
CAS REGISTRY NUMBER :
2975-36-2
LAST UPDATED :
199510
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C19-H22-N2-S.Cl-H
MOLECULAR WEIGHT :
346.95
WISWESSER LINE NOTATION :
T C666 BN ISJ B1- CT6NTJ A1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,28,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,28,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
155 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 6,365,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,28,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,28,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
62 mg/kg
TOXIC EFFECTS :
Behavioral - sleep
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 19,87,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,28,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,28,1972

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

  • mepazine hydrochloride
  • Mepazine hydrochloride monohydrate
  • Tyrocidine, hydrochloride
  • Triprolidine hydrochloride
  • Minoxidil hydrochloride
  • Elacridar hydrochloride
  • (1S,2S)-1-amino-1-(2-fluoro-4-methoxyphenyl)propan-2-ol
  • (1S,2S)-1-amino-1-(5-fluoro-2-methoxyphenyl)propan-2-ol
  • (1S,2S)-1-amino-1-(3-fluoro-5-methoxyphenyl)propan-2-ol
  • (1S,2S)-1-amino-1-(4-fluoro-2-methoxyphenyl)propan-2-ol
  • 3-Amino-3-(4-fluoro-3-methoxyphenyl)propan-1-ol
  • 3-Amino-3-(5-fluoro-2-methoxyphenyl)propan-1-ol
  • 3-Amino-3-(5-methylthiophen-2-YL)butanoic acid
  • (R)-2-(1-Amino-2-methoxyethyl)-6-fluorophenol
  • 1-(4-(Difluoromethyl)phenyl)propan-1-amine
  • 3-(1,3-Dioxolan-2-yl)-2-oxo-propionic acid ethyl ester
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.