Mepazine hydrochloride

Suppliers

Names

[ CAS No. ]:
2975-36-2

[ Name ]:
Mepazine hydrochloride

[Synonym ]:
mepazine hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
444.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₃ClN₂S

[ Molecular Weight ]:
346.91700

[ Flash Point ]:
222.6ºC

[ Exact Mass ]:
346.12700

[ PSA ]:
31.78000

[ LogP ]:
5.43600

[ Vapour Pressure ]:
4.29E-08mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SP2800000

CHEMICAL NAME :: Phenothiazine, 10-((1-methyl-3-piperidyl)methyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 2975-36-2

LAST UPDATED :: 199510

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C19-H22-N2-S.Cl-H

MOLECULAR WEIGHT :: 346.95

WISWESSER LINE NOTATION :: T C666 BN ISJ B1- CT6NTJ A1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,28,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,28,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 155 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 6,365,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,28,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,28,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 62 mg/kg

TOXIC EFFECTS :: Behavioral - sleep

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 19,87,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,28,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,28,1972

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

mepazine hydrochloride
Mepazine hydrochloride monohydrate
Tyrocidine, hydrochloride
Triprolidine hydrochloride
Minoxidil hydrochloride
Elacridar hydrochloride
N-(6-methylpyridin-2-yl)-2-(3-tosyl-1H-indol-1-yl)acetamide
N-(3-acetylphenyl)-1,3,6-trimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
3,4-Dimethyl-1,3-oxazolidin-2-one
4H,6H-Thieno[3,4-B]furan-3-carboxylic acid
6-Chloro-1-benzothiophene-2-carbonyl chloride
2-chloro-6-fluoro-N-(2-(methylthio)phenyl)benzamide
N-[2-(4-chlorophenyl)ethyl]-2,5-dimethylfuran-3-carboxamide
2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-oxoacetic acid
2-[[2-(2-Thienyl)ethyl]amino]ethanol
Piperidine, 1-acetyl-2-(2-propenyl)-

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.