4-[(E)-2-(3-fluorophenyl)-1-phenylethenyl]phenol

Names

[ CAS No. ]:
299-08-1

[ Name ]:
4-[(E)-2-(3-fluorophenyl)-1-phenylethenyl]phenol

[Synonym ]:
1-<3-Fluor-phenyl<-2-<4-hydroxy-phenyl>-2-phenyl-aethylen

Chemical & Physical Properties

[ Density]:
1.201g/cm3

[ Boiling Point ]:
397.2ºC at 760mmHg

[ Molecular Formula ]:
C20H15FO

[ Molecular Weight ]:
290.33100

[ Flash Point ]:
248.2ºC

[ Exact Mass ]:
290.11100

[ PSA ]:
20.23000

[ LogP ]:
5.12020

[ Vapour Pressure ]:
7.07E-07mmHg at 25°C

[ Index of Refraction ]:
1.653

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SL4585000
CHEMICAL NAME :
Phenol, p-(m-fluoro-alpha-phenylstyryl)-
CAS REGISTRY NUMBER :
299-08-1
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H15-F-O
MOLECULAR WEIGHT :
290.35
WISWESSER LINE NOTATION :
QR DYR&U1R CF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
500 mg/kg
SEX/DURATION :
male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 151,475,1964
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
3 mg/kg
SEX/DURATION :
female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 151,475,1964

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-benzyloxybenzophenone
  • 3-Fluorobenzyl chloride

DownStream

Related Compounds

  • 4-[(E)-2-(2-fluorophenyl)-1-phenylethenyl]phenol
  • 4-[(E)-2-(4-fluorophenyl)-1-phenylethenyl]phenol
  • 4-[(Z)-2-bromo-2-(3-fluorophenyl)-1-phenylethenyl]phenol
  • 1-[(E)-2-bromo-2-(3-fluorophenyl)-1-phenylethenyl]-4-phenylmethoxybenzene
  • 1-[(E)-2-bromo-2-(3-fluorophenyl)-1-phenylethenyl]-4-methoxybenzene
  • 4-[(E)-2-(3-Chloro-phenyl)-1-pyridin-2-yl-propenyl]-phenol
  • 4-[3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)piperidine-1-carbonyl]pyridine
  • 4-{3-[3-(Thiophen-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carbonyl}pyridine
  • N-[(4-methoxyphenyl)methyl]-3-[3-(thiophen-2-yl)-1,2,4-oxadiazol-5-yl]piperidine-1-carboxamide
  • Benzyl (S)-2-((4-methoxyphenyl)amino)-2-((R)-2-oxocyclohexyl)acetate
  • 4-(5-{1-[(3-Fluoro-4-methoxyphenyl)methyl]piperidin-3-yl}-1,2,4-oxadiazol-3-yl)pyridine
  • N-(4-ethylphenyl)-2-{3-[3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}acetamide
  • 4-(5-{1-[(4-Fluorophenyl)methyl]piperidin-3-yl}-1,2,4-oxadiazol-3-yl)pyridine
  • 4-(5-{1-[(3,5-Dimethyl-1,2-oxazol-4-yl)methyl]piperidin-3-yl}-1,2,4-oxadiazol-3-yl)pyridine
  • 4-{5-[1-(Furan-2-carbonyl)piperidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine
  • 4-{5-[1-(Thiophene-2-carbonyl)piperidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine
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